Document Detail

Antibiotic prophylaxis for infantile pyloromyotomy.
MedLine Citation:
PMID:  8763182     Owner:  NLM     Status:  MEDLINE    
A retrospective study of 50 patients with infantile hypertrophic pyloric stenosis (IHPS) showed wound infection in six patients. In an attempt to assess the value of antibiotic prophylaxis in infantile pyloromyotomy 150 patients with infantile hypertrophic pyloric stenosis were entered in a prospective randomized controlled study. The infants were allocated to receive a dose of Cefuroxime (30 mg/kg) at induction of anaesthesia or no antibiotic. Eight infants developed wound infection, five in the control group and three in the antibiotic prophylaxis group. Although the difference between the two groups was not statistically significant there was an overall reduction of wound infection (6.5%) compared with pre-trial figures (12%). In order to study the bacterial flora in the umbilicus in these infants, culture swabs were taken from the umbilicus on admission, immediately prior to surgery and from the wound prior to skin closure. It was shown that the umbilicus was not the source of infection.
S Nour; A E MacKinnon; J A Dickson; J Walker
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the Royal College of Surgeons of Edinburgh     Volume:  41     ISSN:  0035-8835     ISO Abbreviation:  J R Coll Surg Edinb     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-09-24     Completed Date:  1996-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503110     Medline TA:  J R Coll Surg Edinb     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  178-80     Citation Subset:  IM    
Children's Hospital, Sheffield, UK.
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MeSH Terms
Antibiotic Prophylaxis*
Cefuroxime / therapeutic use*
Cephalosporins / therapeutic use*
Infant, Newborn
Pyloric Stenosis / surgery*
Surgical Wound Infection / prevention & control*
Reg. No./Substance:
0/Cephalosporins; 55268-75-2/Cefuroxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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