| Antibiotic prophylaxis in vascular reconstructive surgery: a double-blind placebo-controlled study. | |
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MedLine Citation:
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PMID: 3512507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a prospective randomized double-blind study of 141 patients referred for reconstructive vascular surgery on the abdominal aorta and the lower extremities, placebo was compared to antibiotic prophylaxis. The prophylaxis group received three doses of a combination of methicillin, 2 g and netilmicin, 200 mg. Antibiotic prophylaxis reduced postoperative wound infections as compared to placebo, i.e. 4/69 (5.8%) vs. 12/72, (16.7%) respectively (P = 0.04). No graft infections occurred. Two cases of postoperative septicaemia were seen in the placebo group, none in the antibiotic group. Among different procedures aortic-femoral bypass operations showed the highest wound infection rates. The two treatment groups were comparable with regard to all other postoperative complications registered, including nephro- and ototoxicity. The antibiotic regimen was considered safe, but had only marginal value as prophylaxis in vascular reconstructive surgery on the abdominal aorta and the lower extremities. |
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Authors:
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A M Worning; N Frimodt-Møller; P Ostri; T Nilsson; K Højholdt; C Frimodt-Møller |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 17 ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 1986 Jan |
Date Detail:
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Created Date: 1986-04-11 Completed Date: 1986-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 105-13 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aorta, Abdominal / surgery Clinical Trials as Topic Double-Blind Method Female Humans Male Methicillin / adverse effects, therapeutic use* Middle Aged Netilmicin / adverse effects, therapeutic use* Postoperative Complications Premedication* Sepsis / epidemiology, etiology Surgical Wound Infection / epidemiology, microbiology, prevention & control* Vascular Surgical Procedures* |
| Chemical | |
Reg. No./Substance:
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56391-56-1/Netilmicin; 61-32-5/Methicillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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