Document Detail


Antibiotic prophylaxis in vascular reconstructive surgery: a double-blind placebo-controlled study.
MedLine Citation:
PMID:  3512507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a prospective randomized double-blind study of 141 patients referred for reconstructive vascular surgery on the abdominal aorta and the lower extremities, placebo was compared to antibiotic prophylaxis. The prophylaxis group received three doses of a combination of methicillin, 2 g and netilmicin, 200 mg. Antibiotic prophylaxis reduced postoperative wound infections as compared to placebo, i.e. 4/69 (5.8%) vs. 12/72, (16.7%) respectively (P = 0.04). No graft infections occurred. Two cases of postoperative septicaemia were seen in the placebo group, none in the antibiotic group. Among different procedures aortic-femoral bypass operations showed the highest wound infection rates. The two treatment groups were comparable with regard to all other postoperative complications registered, including nephro- and ototoxicity. The antibiotic regimen was considered safe, but had only marginal value as prophylaxis in vascular reconstructive surgery on the abdominal aorta and the lower extremities.
Authors:
A M Worning; N Frimodt-Møller; P Ostri; T Nilsson; K Højholdt; C Frimodt-Møller
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  17     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-11     Completed Date:  1986-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  105-13     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aorta, Abdominal / surgery
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Male
Methicillin / adverse effects,  therapeutic use*
Middle Aged
Netilmicin / adverse effects,  therapeutic use*
Postoperative Complications
Premedication*
Sepsis / epidemiology,  etiology
Surgical Wound Infection / epidemiology,  microbiology,  prevention & control*
Vascular Surgical Procedures*
Chemical
Reg. No./Substance:
56391-56-1/Netilmicin; 61-32-5/Methicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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