Document Detail

Antibiotic prophylaxis in third molar surgery: a review.
MedLine Citation:
PMID:  23159124     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: Controversy exists about the efficacy of antibiotic prophylaxis in preventing complications after lower third molar surgery. For evidence-based recommendation, a review was performed on clinical trials reporting the use of antibiotic prophylaxis compared with no treatment or placebo with "infection" as outcome.
STUDY DESIGN: Useful studies were identified using Embase, Cochrane, and Ovid Medline (1966-January 2011) and references in retrieved reports and review articles. Twenty-three eligible studies were identified and reviewed by independent investigators using 2 quality assessment scales.
RESULTS: The review procedure revealed 15 "low-quality" and 8 "high-quality" articles, with major differences in treatment modalities and heterogeneity of design.
CONCLUSIONS: There is limited evidence supporting the efficacy of commonly used antibiotics in preventing complications after lower third molar removal. Well designed and well reported high-quality randomized trials considering known risk factors and taking clinical outcomes into account are needed to reach final consensus on the efficacy of antibiotic prophylaxis to allow evidence-based recommendations.
Marjolijn A E Oomens; Tymour Forouzanfar
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Publication Detail:
Type:  Journal Article     Date:  2012-05-30
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  114     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e5-e12     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Oral and Maxillofacial Surgery/Oral Pathology, Vrije Universiteit Medical Center/Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands.
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