Document Detail

Antibiotic prophylaxis in genitourinary surgery.
MedLine Citation:
PMID:  7326693     Owner:  NLM     Status:  MEDLINE    
Antibiotic prophylaxis in surgery, particularly genitourinary surgery, has been controversial for years. At best, the results have been more testimonial than scientific because of the failure to observe proper experimental design. A survey of the literature indicates that antibiotic prophylaxis in genitourinary surgery probably has little influence on postoperative fever; it appears to favorably affect the incidence of postoperative bacteriuria and bacteremia in the short term without encouraging nosocomial or resistant infections. The regimen for prophylaxis must be perioperative and continued for no longer than 24 hours postoperatively. Given that antibiotic prophylaxis in elective genitourinary surgery has merit, a comparison between cefazolin and cefotaxime was undertaken. Of 160 evaluable cases, a total of 23 patients had positive cultures within the first nine days; only two occurred within the first five days. When cefazolin and cefotaxime were administered in the same dosage regimen, the infection rate for cefazolin was 19% compared with 10% for cefotaxime.
S J Childs; P D Wood; J W Kosola
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  4 Suppl A     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1981  
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  111-23     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Body Temperature
Microbial Sensitivity Tests
Middle Aged
Urogenital System / surgery*
Reg. No./Substance:
0/Anti-Bacterial Agents

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