Document Detail


Antibiotic prophylaxis in clean neurosurgery.
MedLine Citation:
PMID:  11936354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two regimens of antibiotic prophylaxis are in use at our institution. These protocols consist in perioperative administration of a single dose of amoxicillin-clavulanic acid of 2.2 g at induction and 8 h later and irrigation of the surgical wound with rifamycin before closure. In cases of dirty surgery, placement of external shunts or foreign bodies, we administer vancomycin 1.5 g/die and ceftazidime 6 g/die for 72 h. A retrospective study of all the clean operations we performed in the last 2 years yielded a total of 793 consecutive procedures with three postoperative wound infections. These results are in agreement with the majority of series reported in literature, although different prophylactic protocols are applied and in some cases no prophylactic antibiotics are administered at all. The use of these agents in clean neurosurgery remains, as a matter of fact, controversial. In order to further investigate this issue we took three or more intraoperative samples for culture in 40 clean cases. Only in 2% of these samples were cultures positive. Although lacking statistical significance, these results are interesting indications of the appropriateness of antimicrobial prophylaxis in clean neurosurgery and invite further investigation in that direction.
Authors:
F Cacciola; F Cioffi; P Anichini; N Di Lorenzo
Related Documents :
8331764 - Hand grenade injuries among civilians.
21372354 - Retrospective analysis of duodenal injuries: a comprehensive overview.
20220634 - Understanding wound bed preparation and wound debridement.
21153884 - Leucocyte-depleted blood transfusion is an independent predictor of surgical morbidity ...
11725774 - Aureobasidium pullulans scleritis following keratoplasty: a case report.
22965014 - Making a malleable awl using a steinmann pin for transnasal medial canthopexy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chemotherapy (Florence, Italy)     Volume:  13 Spec No 1     ISSN:  1120-009X     ISO Abbreviation:  J Chemother     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2002-04-08     Completed Date:  2002-09-12     Revised Date:  2009-08-04    
Medline Journal Info:
Nlm Unique ID:  8907348     Medline TA:  J Chemother     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, University of Florence, Italy. francesco@cacciola.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amoxicillin-Potassium Clavulanate Combination / therapeutic use*
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis*
Brain Diseases / surgery*
Drug Therapy, Combination / therapeutic use*
Humans
Neurosurgical Procedures*
Retrospective Studies
Surgical Wound Infection / prevention & control*
Vancomycin / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 1404-90-6/Vancomycin; 74469-00-4/Amoxicillin-Potassium Clavulanate Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of glycopeptides in the treatment of septic complications after cardiac surgery.
Next Document:  Immune system and surgical site infection.