| Antibiotic-associated diarrhoea. | |
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MedLine Citation:
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PMID: 16610966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diarrhoea is a common complication of antimicrobial therapy. The term antibiotic-associated diarrhoea (AAD) is often considered synonymous with Clostridium difficile. In fact, AAD can develop through a variety of mechanisms and manifest through a broad range of clinical signs and symptoms. For improved prevention and recognition of AAD, it is important to understand the pathophysiology and risk factors for AAD. Although Clostridium difficile continues to be the most common identifiable pathogen of AAD, many patients with AAD can be managed through a variety of conservative measures. This review focuses on some of the important distinctions between nonspecific AAD and antibiotic-associated colitis. In addition, the most recent data on important risk factors for the development of AAD are summarised. Given its pathogenicity, there will be an emphasis on the early diagnosis, treatment and prevention of Clostridium difficile-associated diarrhoea. AAD is a common clinical problem that can progress to severe, life-threatening disease if not recognised quickly. Better awareness of risk factors can lead to the most efficacious treatment of this disorder: primary prevention. |
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Authors:
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Gregory A Coté; Alan L Buchman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on drug safety Volume: 5 ISSN: 1744-764X ISO Abbreviation: Expert Opin Drug Saf Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-13 Completed Date: 2007-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101163027 Medline TA: Expert Opin Drug Saf Country: England |
Other Details:
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Languages: eng Pagination: 361-72 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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adverse effects*,
therapeutic use Anti-Infective Agents / therapeutic use Clostridium difficile / drug effects, isolation & purification Colitis / etiology Diarrhea / drug therapy, etiology*, microbiology Enterocolitis, Pseudomembranous / diagnosis, drug therapy, etiology*, prevention & control Humans Penicillins / adverse effects Probiotics / therapeutic use Recurrence / prevention & control Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Penicillins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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