Document Detail


Antibiotic action of Solanum incanum Linnaeus.
MedLine Citation:
PMID:  945715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fruits of Solanum incanum Linnaeus are extensively used in Kenya for the treatment of cutaneous mycotic infections and other pathological conditions. The therapeutic activity of the berries has been attributed to their content of solanine and related glycoalkaloids, which are saponins and cytostatic poisons. In the present study, however, a simpler more potent antimicrobial substance with a phosphorylated structure similar to the purine adenine was isolated from the berries. The crystals of this compound were effective inhibitors of the growth of gram-positive and -negative bacteria, yeasts, dermatophytes, and some pathogens of agricultural produce. High concentrations of the substance caused hemolysis of erythrocytes.
Authors:
V Beaman-Mbaya; S I Muhammed
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  9     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  920-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / pharmacology*
Arthrodermataceae / drug effects*
Bacteria / drug effects
Cattle
Enterobacteriaceae / drug effects*
Erythrocytes / drug effects
Hemolysis / drug effects
Microbial Sensitivity Tests
Mitosporic Fungi / drug effects*
Plant Extracts / pharmacology*
Plants, Medicinal*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Plant Extracts
Comments/Corrections

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