Document Detail


Antibiotic sensitivity of 40 Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant isolates from Beijing, China.
MedLine Citation:
PMID:  22106216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MICs of eight antibiotics were detected with 40 Chinese Mycoplasma pneumoniae isolates. Thirty-eight isolates (95%) were macrolide resistant. Each macrolide-resistant isolate harbored an A2063G or A2064G point mutation in the 23S rRNA gene. All 40 isolates (100%) were type I strains, but they might have originated from different clones.
Authors:
Fei Zhao; Min Lv; Xiaoxia Tao; Hui Huang; Binghua Zhang; Zhen Zhang; Jianzhong Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-21
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  56     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-05-25     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1108-9     Citation Subset:  IM    
Affiliation:
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
China / epidemiology
DNA, Bacterial / genetics
Drug Resistance, Bacterial / genetics*
Genes, rRNA
Humans
Macrolides / pharmacology*
Microbial Sensitivity Tests
Mycoplasma pneumoniae / classification,  drug effects*,  genetics,  isolation & purification
Pneumonia, Mycoplasma / epidemiology,  microbiology*
Point Mutation / drug effects
Polymerase Chain Reaction
RNA, Ribosomal, 23S / genetics
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/DNA, Bacterial; 0/Macrolides; 0/RNA, Ribosomal, 23S
Comments/Corrections

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