Document Detail

Antibacterial titanium plate anodized by being discharged in NaCl solution exhibits cell compatibility.
MedLine Citation:
PMID:  14742647     Owner:  NLM     Status:  MEDLINE    
Implant surfaces should be modified to achieve excellent cell compatibility as well as antibacterial activity. Our previous study demonstrated that titanium plates anodized by being discharged in NaCl (Ti-Cl) exhibited high antibacterial activity. Since Ti-Cl was prepared with a NaCl solution, we hypothesized that Ti-Cl would exhibit low toxicity toward cells. The aims of this study were to characterize the surface of Ti-Cl and investigate the cell compatibility (MC3T3-E1 and L929 cells) of Ti-Cl. The results demonstrated that, since the TiCl(3) formed on the Ti-Cl surface was hydrolyzed into HCl, HClO, and TiOH after immersion in pure distilled water, TiCl(3) contributed to the antibacterial activity of Ti-Cl. On the other hand, TiO formed on the Ti-Cl surface enhanced cell extension and cell growth through a larger adsorption of fibronectin compared with the pure titanium control. These findings suggest that antibacterial titanium is a promising material for use in dental implant systems.
Y Shibata; H Kawai; H Yamamoto; T Igarashi; T Miyazaki
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dental research     Volume:  83     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-26     Completed Date:  2004-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-9     Citation Subset:  D; IM    
Department of Oral Biomaterials and Technology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
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MeSH Terms
3T3 Cells
Anti-Bacterial Agents / chemistry*
Biocompatible Materials / chemistry*
Cell Adhesion
Cell Division
Cell Line
Fibroblasts / cytology
Fibronectins / chemistry
Hydrochloric Acid / chemistry
Hypochlorous Acid / chemistry
Materials Testing
Osteoblasts / cytology
Sodium Chloride / chemistry*
Surface Properties
Titanium / chemistry*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Biocompatible Materials; 0/Fibronectins; 12651-23-9/titanium hydroxide; 13463-67-7/titanium dioxide; 7440-32-6/Titanium; 7647-01-0/Hydrochloric Acid; 7647-14-5/Sodium Chloride; 7790-92-3/Hypochlorous Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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