Document Detail

Antibacterial sphingolipid and steroids from the black coral Antipathes dichotoma.
MedLine Citation:
PMID:  21139269     Owner:  NLM     Status:  MEDLINE    
From the black coral Antipathies dichotoma, a sphingolipid (2S*,3S*,4E,8E)-2N-[tetradecanoyl]-4(E),8(E)-icosadiene-1,3-diol (1) and a steroid (22E)-methylcholesta-5,22-diene-1α,3β,7α-triol (2) were isolated. Other known compounds, 3β,7α-dihydroxy-cholest-5-ene (3), (22E,24S),5α,8α-epidioxy-24-methylcholesta-6,22-dien-3β-ol (4) and (22E,24S),5α,8α-epidioxy-24-methylcholesta-6,9(11),22-trien-3β-ol (5). The structures were established on the basis of NMR spectroscopic analysis and comparison with literature. The antibacterial activity of five compounds was evaluated.
Sultan Samran Al-Lihaibi; Seif-Eldin Nasr Ayyad; Fekry Shaher; Walied Mohamed Alarif
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  58     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-08     Completed Date:  2011-03-24     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1635-8     Citation Subset:  IM    
Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, Saudi Arabia.
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MeSH Terms
Anthozoa / chemistry*
Anti-Bacterial Agents / chemistry*,  isolation & purification,  pharmacology
Dehydrocholesterols / chemistry*,  isolation & purification,  pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Conformation
Sphingolipids / chemistry*,  isolation & purification,  pharmacology
Steroids / chemistry*,  isolation & purification,  pharmacology
Reg. No./Substance:
0/(22E)-methylcholesta-5,22-diene-1alpha,3beta,7alpha-triol; 0/2N-(tetradecanoyl)-4(E),8(E)-icosadiene-1,3-diol; 0/Anti-Bacterial Agents; 0/Dehydrocholesterols; 0/Sphingolipids; 0/Steroids

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