Document Detail

Antibacterial protection of suture material by chlorhexidine-functionalized polyelectrolyte multilayer films.
MedLine Citation:
PMID:  18709445     Owner:  NLM     Status:  MEDLINE    
The formation of bacterial biofilms on the surface of implanted materials is a critical factor that may lead to chronic microbial infection and tissue necrosis. In the present study we analysed the stability of polyelectrolyte multilayer (ML) films on suture materials and the antibacterial effect obtained with chlorhexidine (CHX)-functionalized films built on different types of suture materials such as silk, polyester and copolymer of glycolide and L: -lactide. The comparison of Escherichia coli culture on glass coverslips and glass coverslips with ML and CHX showed at 24 h an inhibition of the bacterial relative luminescence (40.68%, P < 0.5) and at 48 h (99.46%, P < 0.001). In another way, simple soaking of suture material overnight in CHX digluconate 20% without polyelectrolyte films did not at all protect sutures from bacterial colonization but CHX-functionalized polyelectrolyte films, made from poly-L: -glutamic acid and poly-L: -lysine, inhibited Escherichia coli proliferation.
Jean-Claude Harnet; Erell Le Guen; Vincent Ball; Henri Tenenbaum; Joelle Ogier; Youssef Haikel; Constant Vodouhê
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-16
Journal Detail:
Title:  Journal of materials science. Materials in medicine     Volume:  20     ISSN:  0957-4530     ISO Abbreviation:  J Mater Sci Mater Med     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013087     Medline TA:  J Mater Sci Mater Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  185-93     Citation Subset:  IM    
Faculté de chirurgie dentaire, 1 place de l'Hôpital, 67000, Strasbourg, France.
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MeSH Terms
Anti-Bacterial Agents / chemistry*,  pharmacology*
Biocompatible Materials / chemistry*,  pharmacology*
Chlorhexidine / chemistry*,  pharmacology*
Coated Materials, Biocompatible / chemistry
Electrolytes / chemistry
Escherichia coli / drug effects,  growth & development
Materials Testing
Molecular Structure
Polyglutamic Acid / chemistry
Polylysine / chemistry
Polymers / chemistry*
Spectrophotometry, Infrared
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Biocompatible Materials; 0/Coated Materials, Biocompatible; 0/Electrolytes; 0/Polymers; 25104-18-1/Polylysine; 25513-46-6/Polyglutamic Acid; 55-56-1/Chlorhexidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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