Document Detail

Antibacterial properties of chitosan in waterborne pathogen.
MedLine Citation:
PMID:  15328699     Owner:  NLM     Status:  MEDLINE    
The antimicrobial properties of chitosan, a derivative of chitin, were investigated in the solid and liquid culture against bacteria associated with waterborne disease in order to assess the potential for using chitosan as a natural disinfectant. Six strains which included three gram-negative and three gram-positive bacteria were studied. The effects of the deacetylation degree, concentration, and molecular weight of chitosan on antibacterial activities were assessed. Chitosan exhibited the highest antibacterial activity against the Pseudomonas aeruginosa on the solid agar. Similar tendency was found when the bacteria were cultivated in liquid broth. The higher deacetylation degree and higher concentration of chitosan cause the higher antibacterial activities. The effect of molecular weight of chitosan on the inhibition efficacy of bacteria is dependent on the species of bacteria. Escherichia coli is sensitive to chitosan during its death phase and logarithmic phase. The antibacterial mechanism of chitosan was illustrated by the surface charge and persistence length. Results indicated that chitosan is potential as a natural disinfectant.
Yen-Meng Chen; Ying-Chien Chung; Li-Woan Wang; Kung-Tung Chen; Shyh-Yuan Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering     Volume:  37     ISSN:  1093-4529     ISO Abbreviation:  J Environ Sci Health A Tox Hazard Subst Environ Eng     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2004-08-26     Completed Date:  2004-09-10     Revised Date:  2009-08-14    
Medline Journal Info:
Nlm Unique ID:  9812551     Medline TA:  J Environ Sci Health A Tox Hazard Subst Environ Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1379-90     Citation Subset:  IM    
Department of Industrial Engineering and Management, China Institute of Technology, Taipei City, Taiwan 115, R.O.C.
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MeSH Terms
Chelating Agents / pharmacology*
Chitin / analogs & derivatives*,  pharmacology*
Disease Outbreaks / prevention & control*
Disinfectants / pharmacology*
Escherichia coli / pathogenicity*
Microbial Sensitivity Tests
Pseudomonas aeruginosa / pathogenicity*
Structure-Activity Relationship
Water Microbiology
Reg. No./Substance:
0/Chelating Agents; 0/Disinfectants; 1398-61-4/Chitin; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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