Document Detail


Antibacterial properties of cationic steroid antibiotics.
MedLine Citation:
PMID:  12445638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cationic steroid antibiotics have been developed that display broad-spectrum antibacterial activity. These compounds are comprised of steroids appended with amine groups arranged to yield facially amphiphilic morphology. Examples of these antibiotics are highly bactericidal, while related compounds effectively permeabilize the outer membranes of Gram-negative bacteria sensitizing these organisms to hydrophobic antibiotics. Cationic steroid antibiotics exhibit various levels of eukaryote vs. prokaryote cell selectivity, and cell selectivity can be increased via charge recognition of prokaryotic cells. Studies of the mechanism of action of these antibiotics suggest that they share mechanistic aspects with cationic peptide antibiotics.
Authors:
Paul B Savage; Chunhong Li; Uale Taotafa; Bangwei Ding; Qunying Guan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  FEMS microbiology letters     Volume:  217     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2003-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT 84602, USA. paul_savage@byu.edu
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemistry,  pharmacokinetics,  pharmacology*
Antimicrobial Cationic Peptides / metabolism,  pharmacokinetics,  pharmacology*
Bacterial Outer Membrane Proteins / metabolism
Cholestanols / pharmacokinetics
Hemolysis
Microbial Sensitivity Tests
Models, Structural
Polymyxin B / pharmacokinetics
Steroids / chemistry,  classification,  pharmacology
Grant Support
ID/Acronym/Agency:
GM 54619/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antimicrobial Cationic Peptides; 0/Bacterial Outer Membrane Proteins; 0/Cholestanols; 0/Steroids; 1404-26-8/Polymyxin B; 148717-90-2/squalamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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