Document Detail

Antibacterial interactions of monolaurin with commonly used antimicrobials and food components.
MedLine Citation:
PMID:  19895490     Owner:  NLM     Status:  MEDLINE    
Monolaurin is a nontraditional antimicrobial agent that possesses better antimicrobial activities but causes no health problems to consumers, but the use of monolaurin in the food industry as a preservative is still limited. Using a microtiter plate assay, the minimum inhibitory concentrations for monolaurin were 25 microg/mL against Escherichia coli, 12.5 microg/mL against Staphylococcus aureus, and 30 microg/mL against Bacillus subtilis. The interaction with commonly used antimicrobials revealed that monolaurin and nisin acted synergistically against the test microorganisms, monolaurin in combination with sodium dehydroacetate or ethylenediaminetetraacetic acid was synergistic against E. coli and B. subtilis but not S. aureus, and monolaurin combined with calcium propionate or sodium lactate showed no synergistic effects against any test microorganism. The interaction with food components revealed that the antibacterial effectiveness of monolaurin was reduced by fat or starch while the monolaurin activity remained unchanged in the presence of protein. This study contributes to a better understanding on the use of monolaurin as a nontraditional preservative in food products. Results from this study suggest the potential use of monolaurin as a nontraditional preservative in combination with commonly used antimicrobials, such as nisin, sodium dehydroacetate, or ethylenediaminetetraacetic acid, and suggest that the antibacterial effectiveness of monolaurin may be reduced significantly in high-fat or low-starch food products.
Hui Zhang; Hewen Wei; Yinan Cui; Guoqun Zhao; Fengqin Feng
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of food science     Volume:  74     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  M418-21     Citation Subset:  IM    
Dept of Food Science and Nutrition, Huajiachi Campus, Zhejiang Univ, Hangzhou 310029, China.
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Bacillus subtilis / drug effects
Dietary Carbohydrates
Dietary Fats
Dietary Proteins
Drug Synergism
Edetic Acid / pharmacology*
Escherichia coli / drug effects
Food Microbiology*
Food Preservatives / pharmacology
Food-Drug Interactions*
Laurates / pharmacology*
Microbial Sensitivity Tests
Monoglycerides / pharmacology*
Nisin / pharmacology*
Propionic Acids / pharmacology
Pyrones / pharmacology*
Sodium Lactate / pharmacology
Staphylococcus aureus / drug effects
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Food Preservatives; 0/Laurates; 0/Monoglycerides; 0/Propionic Acids; 0/Pyrones; 0/calcium propionate; 1414-45-5/Nisin; 27215-38-9/monolaurin; 520-45-6/dehydroacetic acid; 60-00-4/Edetic Acid; 72-17-3/Sodium Lactate

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