| Antibacterial efficacy of MTAD final rinse and two percent chlorhexidine gel medication in teeth with apical periodontitis: a randomized double-blinded clinical trial. | |
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MedLine Citation:
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PMID: 19840635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Clinical assessment of the efficacy of novel root canal disinfection protocols is an important focus in endodontic research. This randomized double-blinded study assessed the antibacterial efficacy of a final rinse with BioPure MTAD (MTAD) and intracanal medication with 2% chlorhexidine gel (CHX) in teeth with apical periodontitis. METHODS: Canals in 30 teeth (single-rooted and multi-rooted) were prepared by using 1.3% NaOCl, rinsed with MTAD or saline in random sequence, medicated with CHX for 7 days, irrigated with 1.3% NaOCl, and filled. Bacteriologic root canal samples were obtained by aspiration before (1A) and after (1B) canal preparation, after the final rinse (1C), after CHX was flushed (2A), and after final irrigation (2B). Bacteria were enumerated by epifluorescence-microscopy (EFM) by using 2 staining methods and by colony-forming-unit (CFU) counts after 14 days of incubation. RESULTS: Bacterial counts (EFM) in 1B were greater than 95% decreased from 1A. Low bacterial densities in 1B, 1C, 2A, and 2B did not differ significantly from each other. EFM counts were consistently higher than CFU counts. CONCLUSIONS: The final rinse with MTAD and medication with CHX did not reduce bacterial counts beyond levels achieved by canal preparation with NaOCl. |
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Authors:
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Gevik Malkhassian; Aldo J Manzur; Milos Legner; Edward D Fillery; Sheela Manek; Bettina R Basrani; Shimon Friedman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-09-18 |
Journal Detail:
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Title: Journal of endodontics Volume: 35 ISSN: 1878-3554 ISO Abbreviation: J Endod Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-20 Completed Date: 2010-01-26 Revised Date: 2010-03-26 |
Medline Journal Info:
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Nlm Unique ID: 7511484 Medline TA: J Endod Country: United States |
Other Details:
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Languages: eng Pagination: 1483-90 Citation Subset: D |
Affiliation:
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Department of Endodontics, Faculty of Dentistry, University of Toronto, Ontario, Canada. gevik.malkhassian@dentistry.utoronto.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Bacterial Agents / therapeutic use* Anti-Infective Agents, Local / therapeutic use* Bacteria, Aerobic / isolation & purification Bacteria, Anaerobic / isolation & purification Chlorhexidine / therapeutic use* Citric Acid / therapeutic use* Cohort Studies Colony Count, Microbial Dental Pulp Cavity / microbiology Dental Restoration, Permanent / methods Double-Blind Method Doxycycline / therapeutic use* Female Glass Ionomer Cements Gutta-Percha / therapeutic use Humans Male Microscopy, Fluorescence Middle Aged Periapical Periodontitis / microbiology, therapy* Polysorbates / therapeutic use* Resins, Synthetic Root Canal Filling Materials / therapeutic use Root Canal Irrigants / therapeutic use* Root Canal Obturation Root Canal Preparation / instrumentation, methods* Sodium Hypochlorite / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents, Local; 0/Glass Ionomer Cements; 0/MTAD (intracanal irrigant); 0/Photac-Fil; 0/Polysorbates; 0/Resins, Synthetic; 0/Root Canal Filling Materials; 0/Root Canal Irrigants; 55-56-1/Chlorhexidine; 564-25-0/Doxycycline; 7681-52-9/Sodium Hypochlorite; 77-92-9/Citric Acid; 9000-32-2/Gutta-Percha |
| Comments/Corrections | |
Comment In:
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J Endod. 2010 Apr;36(4):596; author reply 596-7
[PMID:
20307729
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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