Document Detail

Antibacterial effect of garlic and omeprazole on Helicobacter pylori.
MedLine Citation:
PMID:  10404325     Owner:  NLM     Status:  MEDLINE    
The antibacterial effect of a home-made raw garlic extract and commercial garlic tablets alone and in combination with antibiotics or omeprazole was determined against clinical isolates of Helicobacter pylori. MIC values of raw garlic extract and three types of commercial garlic tablets ranged from 10,000 to 17,500 mg/L. When MIC values of the commercial tablets were based on the allicin content, no differences between the three types were observed. The combination of garlic and omeprazole, studied with killing curves, showed a synergic effect which was concentration dependent. Further clinical evaluation of garlic in combination with the conventional agents for H. pylori treatment seems warranted.
D Jonkers; E van den Broek; I van Dooren; C Thijs; E Dorant; G Hageman; E Stobberingh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  43     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-09-30     Completed Date:  1999-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  837-9     Citation Subset:  IM    
Department of Medical Microbiology, University Hospital Maastricht, The Netherlands.
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MeSH Terms
Anti-Bacterial Agents / pharmacology
Anti-Ulcer Agents / pharmacology*
Drug Synergism
Garlic / chemistry*
Helicobacter pylori / drug effects*,  isolation & purification
Microbial Sensitivity Tests
Omeprazole / pharmacology*
Plant Extracts / pharmacology
Plants, Medicinal*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Plant Extracts; 73590-58-6/Omeprazole

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