Document Detail


Antibacterial effect of the bioactive compound beauvericin produced by Fusarium proliferatum on solid medium of wheat.
MedLine Citation:
PMID:  20371252     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To obtain the bioactive compound beauvericin (BEA), Fusarium proliferatum CECT 20569 was grown on a solid medium of wheat, utilizing the technique of the solid state fermentation (SSF), being this mycotoxin purified by high performance liquid chromatography (HPLC) with a reverse phase semi-preparative column using as the mobile phase acetonitrile/water in gradient condition. The purity of the BEA was verified by analytical HPLC and liquid chromatography tandem mass spectrometry (LC/MS-MS). The pure fractions of BEA were utilized to determinate the antibiotic effects on several bacterial strains that are considered normally pathogens of the intestinal tract as: Escherichia coli, Enterococcus faecium, Salmonella enterica, Shigella dysenteriae, Listeria monocytogenes, Yersinia enterocolitica, Clostridium perfringens, Pseudomonas aeruginosa and Staphylococcus aureus.
Authors:
G Meca; I Sospedra; J M Soriano; A Ritieni; A Moretti; J Mañes
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-03
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  56     ISSN:  1879-3150     ISO Abbreviation:  Toxicon     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  349-54     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Spain. giuseppe.meca@uv.es
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*
Chromatography, Liquid
Depsipeptides / pharmacology*
Fusarium / metabolism*
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Tandem Mass Spectrometry
Triticum / metabolism*,  microbiology
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Depsipeptides; 26048-05-5/beauvericin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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