| Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin. | |
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MedLine Citation:
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PMID: 21425665 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The antimicrobial and cytotoxic activities of chloroform extracts from the weeds Centaurea tweediei and C. diffusa, and the main sesquiterpene lactones isolated from these species, onopordopicrin and cnicin, respectively, were assayed. Results show that the chloroform extracts from both Centaurea species possess antibacterial activities against a panel of Gram-positive and Gram-negative bacteria. Remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus was also measured. Both the extracts and the purified sesquiterpene lactones show high cytotoxicity against human-derived macrophages. Despite this cytotoxicity, C. diffusa chloroform extract and cnicin are attractive candidates for evaluation as antibiotics in topical preparations against skin-associated pathogens. |
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Authors:
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Sandra M Bach; Mario A Fortuna; Rodgoun Attarian; Juliana T de Trimarco; César A N Catalán; Yossef Av-Gay; Horacio Bach |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Natural product communications Volume: 6 ISSN: 1934-578X ISO Abbreviation: Nat Prod Commun Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101477873 Medline TA: Nat Prod Commun Country: United States |
Other Details:
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Languages: eng Pagination: 163-6 Citation Subset: IM |
Affiliation:
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Division of Infectious Diseases, Department of Medicine, University of British Columbia, 2733 Heather Street, Vancouver, V5Z 3J5, Canada. hbach@interchange.ubc.ca |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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