Document Detail


Antibacterial and antiviral naphthazarins from Maharanga bicolor.
MedLine Citation:
PMID:  17867562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maharanga bicolor, Boraginaceae, is used in the Nepalese ethnomedicine for the treatment of several diseases. In the course of screening investigations the dichloromethane extract of the roots of Maharanga bicolor was found to inhibit the growth of gram positive bacteria. Bio-assay directed fractionation led to the isolation of five active naphthazarins, deoxyalkannin (1), alkannin (2), acetylalkannin (3), alkannin beta-hydroxyisovalerate (4) and alkannin beta-acetoxyisovalerate (5). Compounds 2-5 showed antibacterial activity against multi resistant human pathogenic Staphylococcus and Enterococcus species and 1, 4 and 5 showed antiviral activity against herpes simplex virus type-1.
Authors:
M Rajbhandari; T H Schoepke; R Mentel; U Lindequist
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Die Pharmazie     Volume:  62     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  633-5     Citation Subset:  IM    
Affiliation:
Research Center for Applied Science and Technology, Tribhuvan University, Kathmandu, Nepal.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents*
Antineoplastic Agents, Phytogenic / pharmacology
Antiviral Agents*
Bacillus subtilis / drug effects
Boraginaceae / chemistry*
Cell Line, Tumor
Cercopithecus aethiops
Dogs
Enterococcus / drug effects
Gram-Positive Bacteria / drug effects
Herpesvirus 1, Human / drug effects
Influenza A virus / drug effects
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Naphthoquinones / isolation & purification,  pharmacology*
Nepal
Plant Extracts / chemistry
Solvents
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Staphylococcus / drug effects
Structure-Activity Relationship
Vero Cells
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antineoplastic Agents, Phytogenic; 0/Antiviral Agents; 0/Naphthoquinones; 0/Plant Extracts; 0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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