Document Detail


Antibacterial amorphous calcium phosphate nanocomposites with a quaternary ammonium dimethacrylate and silver nanoparticles.
MedLine Citation:
PMID:  22305716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Calcium and phosphate ion-releasing resin composites are promising for remineralization. However, there has been no report on incorporating antibacterial agents to these composites. The objective of this study was to develop antibacterial and mechanically strong nanocomposites incorporating a quaternary ammonium dimethacrylate (QADM), nanoparticles of silver (NAg), and nanoparticles of amorphous calcium phosphate (NACP).
METHODS: The QADM, bis(2-methacryloyloxyethyl) dimethylammonium bromide (ionic dimethacrylate-1), was synthesized from 2-(N,N-dimethylamino)ethyl methacrylate and 2-bromoethyl methacrylate. NAg was synthesized by dissolving Ag 2-ethylhexanoate salt in 2-(tert-butylamino)ethyl methacrylate. Mechanical properties were measured in three-point flexure with bars of 2 mm×2 mm×25 mm (n=6). Composite disks (diameter=9 mm, thickness=2 mm) were inoculated with Streptococcus mutans. The metabolic activity and lactic acid production of biofilms were measured (n=6). Two commercial composites were used as controls.
RESULTS: Flexural strength and elastic modulus of NACP+QADM, NACP+NAg, and NACP+QADM+NAg matched those of commercial composites with no antibacterial property (p>0.1). The NACP+QADM+NAg composite decreased the titer counts of adherent S. mutans biofilms by an order of magnitude, compared to the commercial composites (p<0.05). The metabolic activity and lactic acid production of biofilms on NACP+QADM+NAg composite were much less than those on commercial composites (p<0.05). Combining QADM and NAg rendered the nanocomposite more strongly antibacterial than either agent alone (p<0.05).
SIGNIFICANCE: QADM and NAg were incorporated into calcium phosphate composite for the first time. NACP+QADM+NAg was strongly antibacterial and greatly reduced the titer counts, metabolic activity, and acid production of S. mutans biofilms, while possessing mechanical properties similar to commercial composites. These nanocomposites are promising to have the double benefits of remineralization and antibacterial capabilities to inhibit dental caries.
Authors:
Lei Cheng; Michael D Weir; Hockin H K Xu; Joseph M Antonucci; Alison M Kraigsley; Nancy J Lin; Sheng Lin-Gibson; Xuedong Zhou
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-02
Journal Detail:
Title:  Dental materials : official publication of the Academy of Dental Materials     Volume:  28     ISSN:  1879-0097     ISO Abbreviation:  Dent Mater     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-09-25     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  8508040     Medline TA:  Dent Mater     Country:  England    
Other Details:
Languages:  eng     Pagination:  561-72     Citation Subset:  D    
Copyright Information:
Copyright © 2012 Academy of Dental Materials. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Acrylic Resins / chemistry
Anti-Bacterial Agents / chemistry,  pharmacology*
Bacterial Adhesion / drug effects
Bacterial Load / drug effects
Biofilms / drug effects
Bisphenol A-Glycidyl Methacrylate / chemistry
Calcium Phosphates / chemistry,  pharmacology*
Composite Resins / chemistry,  pharmacology*
Dental Materials / chemistry,  pharmacology*
Elastic Modulus
Fluorides / chemistry,  pharmacology
Glass / chemistry
Humans
Lactic Acid / analysis
Materials Testing
Methacrylates / chemistry,  pharmacology
Microbial Viability / drug effects
Microscopy, Electron, Transmission
Nanocomposites / chemistry*
Nanoparticles / chemistry
Pliability
Polyethylene Glycols / chemistry
Polymethacrylic Acids / chemistry
Polyurethanes / chemistry
Quaternary Ammonium Compounds / chemistry,  pharmacology*
Silver / chemistry,  pharmacology*
Streptococcus mutans / drug effects
Grant Support
ID/Acronym/Agency:
R01 DE017974/DE/NIDCR NIH HHS; R01 DE017974-03/DE/NIDCR NIH HHS; R01 DE017974-04/DE/NIDCR NIH HHS; R01 DE14190/DE/NIDCR NIH HHS; R01 DE17974/DE/NIDCR NIH HHS; Y1-DE-7005-01/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Acrylic Resins; 0/Anti-Bacterial Agents; 0/Calcium Phosphates; 0/Composite Resins; 0/Dental Materials; 0/Heliomolar; 0/Methacrylates; 0/Polyethylene Glycols; 0/Polymethacrylic Acids; 0/Polyurethanes; 0/Quaternary Ammonium Compounds; 0/amorphous calcium phosphate; 0/poly(2-(tert-butylamino)ethyl methacrylate); 109-16-0/triethylene glycol dimethacrylate; 33X04XA5AT/Lactic Acid; 3M4G523W1G/Silver; 454I75YXY0/Bisphenol A-Glycidyl Methacrylate; Q80VPU408O/Fluorides
Comments/Corrections

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