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Antibacterial activity of long-chain fatty alcohols against Mycobacteria.
MedLine Citation:
PMID:  23136919     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tuberculosis is a dreadful disease that results in innumerable deaths across the world that is caused by bacterium Mycobacterium tuberculosis. Emergence of multi drug resistance (MDR) and extremely drug resistance tuberculosis (XDR) strains and its co-infection with HIV has made tuberculosis more difficult to treat. Therefore, new anti-mycobacterial agent(s) for both therapy and disinfection is need of the hour. In this context the present study describes the antibacterial property of long chain fatty alcohols against mycobacteria. The anti-mycobacterial activities of alcohols with chain length ranging from C(5) to C(13) were examined against Mycobacterium smegmatis mc(2) 155 and Mycobacterium tuberculosis H(37) R(v.) The best activity was found with the one containing 10 carbon (C(10) ). This bactericidal activity can partly be attributed to its ability to damage the robust and complex cell envelop of Mycobacteria. Moreover our study reveals the ability of decanol to attenuate biofilm formation by M. smegmatis. The knowledge gained in this study can be used to develop new therapeutics and disinfectants against mycobacteria. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Authors:
Koushik Mukherjee; Prosun Tribedi; Balaram Mukhopadhyay; Alok Kumar Sil
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Publication Detail:
Type:  LETTER     Date:  2012-11-9
Journal Detail:
Title:  FEMS microbiology letters     Volume:  -     ISSN:  1574-6968     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Affiliation:
Department of Microbiology, University of Calcutta, 35, B. C. Road, Kolkata, 700019.
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