Document Detail

Antibacterial activity of ciprofloxacin and trimethoprim, alone and in combinittion, against Vibrio cholerae O1 biotype El Tor serotype Ogawa isolates.
MedLine Citation:
PMID:  19469287     Owner:  NLM     Status:  MEDLINE    
In this communication, the ciprofloxacin-trimethoprim (Cp-Tm) combination showed synergistic (Fractional Inhibitory Concentration, FIC index 0.399) and additive (FIC index 0.665-0.83) effects against Vibrio cholerae O1 biotype El Tor serotype Ogawa isolates having Cp MICs 10 microg/ml and Cp 0.66 microg/ml, respectively, following agar dilution checkerboard method. The time-kill study results demonstrated synergy between Cp and Tm against both groups of isolates providing 2.04 log10 (for strain with Cp MIC 0.66 microg/ml) and 3.12 log10 (for strain with Cp MIC 10 microg/ml) decreases in CFU/ml between the combination and its most active compound. Thus, the findings of the present study suggest an introduction of Cp-Tm combination treatment regimen against drug resistant cholera and this in turn will help in combating the drug resistance of V. cholerae O1 biotype El Tor serotype Ogawa.
Shyamapada Mandal; Nishith K Pal; Imran H Chowdhury; Manisha Debmandal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Polish journal of microbiology / Polskie Towarzystwo Mikrobiologów = The Polish Society of Microbiologists     Volume:  58     ISSN:  1733-1331     ISO Abbreviation:  Pol. J. Microbiol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-27     Completed Date:  2009-06-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101229003     Medline TA:  Pol J Microbiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  57-60     Citation Subset:  IM    
Department of Microbiology, Bacteriology and Serology Unit, Calcutta School of Tropical Medicine, C. R. Avenue, Kolkata-700 073, India.
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MeSH Terms
Anti-Infective Agents, Urinary / therapeutic use
Cholera / drug therapy*
Ciprofloxacin / therapeutic use*
Drug Resistance, Multiple, Bacterial
Drug Therapy, Combination
Microbial Sensitivity Tests
Trimethoprim / therapeutic use*
Vibrio cholerae O1 / drug effects*,  isolation & purification
Reg. No./Substance:
0/Anti-Infective Agents, Urinary; 738-70-5/Trimethoprim; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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