Document Detail


Antibacterial activities of dendritic amphiphiles against nontuberculous mycobacteria.
MedLine Citation:
PMID:  22209468     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The anti-mycobacterial activities of nine series of dicarboxyl and tricarboxyl dendritic amphiphiles with one alkyl, two alkyl, and cholestanyl tails against Mycobacterium abscessus, Mycobacterium avium, Mycobacterium chelonae, Mycobacterium marinum and Mycobacterium smegmatis have been measured. The dendritic amphiphiles overcame the limited aqueous solubility of natural long-chain fatty acids, alcohols, and amines to enable profiling the susceptibilities of the different mycobacterial species to the physicochemical properties of these amphiphiles. Several dendritic amphiphiles showed strong anti-mycobacterial activity with high critical micelle concentrations and low hemolytic activities thereby offering platforms for the development of antibiotics of higher activity against nontuberculous mycobacteria.
Authors:
Joseph O Falkinham; Richard V Macri; Bhadreshkumar B Maisuria; Marcelo L Actis; Eko W Sugandhi; André A Williams; Alyson V Snyder; Faunice R Jackson; Michael A Poppe; Liang Chen; Krithika Ganesh; Richard D Gandour
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-30
Journal Detail:
Title:  Tuberculosis (Edinburgh, Scotland)     Volume:  -     ISSN:  1873-281X     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100971555     Medline TA:  Tuberculosis (Edinb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biological Science (0406), Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
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