Document Detail

Antibacterial activity of nanosilver ions and particles.
MedLine Citation:
PMID:  20583805     Owner:  NLM     Status:  MEDLINE    
The antibacterial activity of nanosilver against Gram negative Escherichia coli bacteria is investigated by immobilizing nanosilver on nanostructured silica particles and closely controlling Ag content and size. These Ag/SiO(2) nanoparticles were characterized by S/TEM, EDX spectroscopy, X-ray diffraction the exposed Ag surface area was measured qualitatively by O(2) chemisorption. Furthermore, the fraction of dissolved nanosilver was determined by measuring the released (leached) Ag(+) ion concentration in aqueous suspensions of such Ag/SiO(2) particles. The antibacterial effect of Ag(+) ions was distinguished from that of nanosilver particles by monitoring the growth of E. coli populations in the presence and absence of Ag/SiO(2) particles. The antibacterial activity of nanosilver was dominated by Ag(+) ions when fine Ag nanoparticles (less than about 10 nm in average diameter) were employed that release high concentrations of Ag(+) ions. In contrast, when relatively larger Ag nanoparticles were used, the concentration of the released Ag(+) ions was lower. Then the antibacterial activity of the released Ag(+) ions and nanosilver particles was comparable.
Georgios A Sotiriou; Sotiris E Pratsinis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental science & technology     Volume:  44     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5649-54     Citation Subset:  IM    
Particle Technology Laboratory, Institute of Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, CH-8092 Zurich, Switzerland.
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MeSH Terms
Anti-Bacterial Agents / chemistry,  pharmacology*
Escherichia coli / drug effects*
Metal Nanoparticles / chemistry*
Particle Size
Silver / chemistry,  pharmacology*
Reg. No./Substance:
0/Anti-Bacterial Agents; 7440-22-4/Silver

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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