| Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids. | |
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MedLine Citation:
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PMID: 16919516 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Omega-3 fatty acids from both marine and plant sources have been shown to reduce the risk of coronary artery disease death. Although their beneficial cardiovascular effects are thought to be due to their antiarrhythmic properties, omega-3 fatty acids also have been shown to have a wide range of antiatherosclerotic and antithrombotic effects in animal and human studies. Review of the findings of randomized, controlled trials published through August 2005 shows that omega-3 fatty acids of marine origin consistently lower elevated plasma triglyceride levels in a dose-dependent fashion, with greater efficacy at higher triglyceride levels. Smaller effects on lowering blood pressure, improving endothelial function, and increasing plasma levels of high-density lipoprotein cholesterol were also found. No consistent effects on other lipid, hemostatic, inflammatory, glucose tolerance, or plaque stabilization parameters were found. Epidemiologic studies show more consistent reductions in the incidence of nonfatal myocardial infarction and ischemic stroke than do the clinical trials of increased omega-3 fatty acid intake, which suggests important confounding factors in observational studies. Ongoing clinical trials may clarify the non-antiarrhythmic benefits of omega-3 fatty acid supplementation. |
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Authors:
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Jennifer G Robinson; Neil J Stone |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-05-30 |
Journal Detail:
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Title: The American journal of cardiology Volume: 98 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-09-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 39i-49i Citation Subset: AIM; IM |
Affiliation:
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Department of Epidemiology, University of Iowa, Iowa City, Iowa 52242, USA. jennifer-g-robinson@uiowa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / therapeutic use Apolipoproteins / drug effects, metabolism Blood Pressure / drug effects Coronary Artery Disease / epidemiology, physiopathology, prevention & control* Dose-Response Relationship, Drug Endothelium, Vascular / drug effects, metabolism, physiopathology Exercise Tolerance / drug effects Fatty Acids, Omega-3 / administration & dosage, therapeutic use* Fatty Acids, Omega-6 / therapeutic use Fibrinolytic Agents / administration & dosage, therapeutic use* Humans Lipid Peroxidation / drug effects Lipoproteins / drug effects, metabolism Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Apolipoproteins; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fibrinolytic Agents; 0/Lipoproteins |
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