Document Detail


Antiatherogenic effects of cilostazol and probucol alone, and in combination in low density lipoprotein receptor-deficient mice fed with a high fat diet.
MedLine Citation:
PMID:  18404599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cilostazol, an antiplatelet drug, and probucol, a cholesterol-lowering drug, are reported to ameliorate atherosclerosis in animal models. However, their combined effect on atherosclerosis is unclear. We therefore evaluated their combined effect on atherosclerotic lesions in LDL receptor-deficient mice. Male LDL receptor-deficient mice were fed a high fat diet with or without cilostazol alone, probucol alone, or with cilostazol and probucol in combination, for 8 weeks. Body weight and plasma lipid levels were measured before and during treatment. At the end of treatment, the size distribution of plasma lipoproteins was analyzed by HPLC and then plasma HDL cholesterol levels and en face aortic atherosclerotic lesion areas were measured. Probucol alone significantly decreased both total cholesterol and HDL cholesterol, while cilostazol alone did not decrease total cholesterol, but significantly increased HDL cholesterol. Both cilostazol alone and probucol alone significantly decreased atherosclerotic lesion areas, and their combined administration showed more significant decreases than when each drug was administered singly. The combination of cilostazol and probucol was more effective in preventing atherosclerotic lesion formation than the administration of each drug alone; this may provide us with a new strategy for treating atherosclerosis.
Authors:
T Yoshikawa; K Mitani; K Kotosai; M Nozako; G Miyakoda; Y Yabuuchi
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Publication Detail:
Type:  Journal Article     Date:  2008-04-10
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  40     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-10-06     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  473-8     Citation Subset:  IM    
Affiliation:
Free Radical Research Institute, Ostuka Pharmaceutical Co., Ltd., Tokushima, Japan. t_yoshikawa@research.otsuka.co.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticholesteremic Agents / administration & dosage,  pharmacology
Aorta / drug effects,  pathology
Apolipoprotein A-I / blood
Atherosclerosis / prevention & control*
Cholesterol / blood
Diet, Atherogenic*
Drug Combinations
Drug Evaluation, Preclinical
Male
Mice
Mice, Knockout
Probucol / administration & dosage*,  pharmacology
Receptors, LDL / genetics*
Tetrazoles / administration & dosage*,  pharmacology
Chemical
Reg. No./Substance:
0/APOA1 protein, human; 0/Anticholesteremic Agents; 0/Apolipoprotein A-I; 0/Drug Combinations; 0/Receptors, LDL; 0/Tetrazoles; 23288-49-5/Probucol; 57-88-5/Cholesterol; N7Z035406B/cilostazol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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