Document Detail

Antiasthma drugs: quality-of-life rating scales and sensitivity to longitudinal change.
MedLine Citation:
PMID:  10147468     Owner:  NLM     Status:  MEDLINE    
The causal hypothesis of quality of life predicts that questionnaire items measuring the construct of problems are more sensitive to change in a clinical trial compared with those measuring the construct of evaluations. This prediction was confirmed in 2 clinical trials of patients with asthma who were administered salmeterol in comparison with another treatment. These and other data show that whether a significant effect is obtained in a clinical trial, and the size of any effect, depend on the properties of the questionnaire used to assess quality of life. Quantitative assessments of improvement in quality of life should be treated with caution in economic evaluations.
M E Hyland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  PharmacoEconomics     Volume:  6     ISSN:  1170-7690     ISO Abbreviation:  Pharmacoeconomics     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-23     Completed Date:  1994-11-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9212404     Medline TA:  Pharmacoeconomics     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  324-9     Citation Subset:  T    
Department of Psychology, University of Plymouth, England.
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MeSH Terms
Albuterol / analogs & derivatives*
Asthma / drug therapy,  psychology*
Longitudinal Studies
Quality of Life*
Reg. No./Substance:

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