| Antiarrhythmics After Ablation of Atrial Fibrillation (5A Study) Six Month Follow-Up Study. | |
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MedLine Citation:
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PMID: 21076158 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: -We previously demonstrated that treatment with antiarrhythmic drugs (AADs) during the first 6-weeks after AF ablation reduces the incidence of clinically significant atrial arrhythmias and need for cardioversion or hospitalization for arrhythmia management. Whether early rhythm suppression decreases longer term arrhythmia recurrence is unknown. We now report the 6-month follow-up data from this study. METHODS AND RESULTS: -The 5A study prospectively randomized patients with paroxysmal AF undergoing ablation to either receive (AAD group) or not receive (no-AAD group) AAD treatment for the first 6-weeks after ablation; all patients received AV nodal blockers. Physicians were encouraged to stop the AADs following the 6-week treatment period. All patients underwent 4-weeks of transtelephonic monitoring to document asymptomatic AF and evaluation at 6 weeks and 6 months. 110 patients (age 55 ± 9 yrs, 71% male) were randomized, 53 to AAD and 57 to no-AAD. At 6 months, there was no difference in freedom from AF between the early AAD and no-AAD groups (38/53 (72%) vs 39/57 (68%); p=0.84). Lack of early AF recurrence during the initial 6-week period was the only independent predictor of 6-month freedom from AF (64/76 (84%) without early recurrence vs. 13/34 (38%) with early recurrence; p=0.0001). CONCLUSIONS: -While short-term use of AADs after AF ablation decreases early recurrence of atrial arrhythmias, early use of AADs does not prevent arrhythmia recurrence at 6 months. Early AF recurrence on or off AAD during the initial 6-week "blanking period" is a strong independent predictor of long term AF recurrence. Clinical Trial Registration-http://www.clinicaltrials.gov; Unique Identifier: NCT00408200. |
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Authors:
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Peter Leong-Sit; Jean-Francois Roux; Erica Zado; David J Callans; Fermin Garcia; David Lin; Francis E Marchlinski; Rupa Bala; Sanjay Dixit; Michael Riley; Matthew D Hutchinson; Joshua Cooper; Andrea M Russo; Ralph Verdino; Edward P Gerstenfeld |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-11-13 |
Journal Detail:
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Title: Circulation. Arrhythmia and electrophysiology Volume: - ISSN: 1941-3084 ISO Abbreviation: Circ Arrhythm Electrophysiol Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101474365 Medline TA: Circ Arrhythm Electrophysiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Hospital of the University of Pennsylvania, Philadelphia, PA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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