Document Detail


Antiarrhythmic vs. antifibrillatory activity of the basic diphenylhydantoin derivative 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-methoxyphenyl)-5-phenylhydantoin hydrochloride.
MedLine Citation:
PMID:  3707667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-methoxyphenyl)-5-phenylhydantoin hydrochloride (TR 2985), a basic diphenylhydantoin derivative, were studied in four canine models of experimental cardiac dysrhythmias. In conscious dogs, 48 h after myocardial infarction, TR 2985 significantly reduced the frequency of spontaneous ventricular arrhythmias. However, in anesthetized dogs, TR 2985 produced only a slight and insignificant increase in the ventricular fibrillation threshold. In conscious dogs, 4 to 7 days after myocardial infarction, TR 2985 failed to prevent the electrical induction of reentrant ventricular tachycardia, and failed to protect against the development of ventricular fibrillation in response to ischemia at a site distant from the previous infarction. These results indicate that TR 2985 may be effective in preventing arrhythmias of a non-reentrant nature, but may be relatively ineffective in preventing reentrant ventricular tachycardia or ventricular fibrillation.
Authors:
J Lynch; D Montgomery; A Ventura; D Wilber; B R Lucchesi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  36     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-06-09     Completed Date:  1986-06-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  475-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General
Animals
Anti-Arrhythmia Agents / pharmacology*
Arrhythmias, Cardiac / drug therapy
Coronary Circulation / drug effects
Coronary Disease / drug therapy
Dogs
Electric Stimulation
Electrocardiography
Heart Ventricles / drug effects,  physiopathology
Male
Myocardial Infarction / drug therapy
Phenytoin / administration & dosage,  analogs & derivatives*,  pharmacology
Tachycardia / drug therapy
Grant Support
ID/Acronym/Agency:
HL-05806-23/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 56079-80-2/ropitoin hydrochloride; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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