| Antiarrhythmic vs. antifibrillatory activity of the basic diphenylhydantoin derivative 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-methoxyphenyl)-5-phenylhydantoin hydrochloride. | |
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MedLine Citation:
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PMID: 3707667 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-methoxyphenyl)-5-phenylhydantoin hydrochloride (TR 2985), a basic diphenylhydantoin derivative, were studied in four canine models of experimental cardiac dysrhythmias. In conscious dogs, 48 h after myocardial infarction, TR 2985 significantly reduced the frequency of spontaneous ventricular arrhythmias. However, in anesthetized dogs, TR 2985 produced only a slight and insignificant increase in the ventricular fibrillation threshold. In conscious dogs, 4 to 7 days after myocardial infarction, TR 2985 failed to prevent the electrical induction of reentrant ventricular tachycardia, and failed to protect against the development of ventricular fibrillation in response to ischemia at a site distant from the previous infarction. These results indicate that TR 2985 may be effective in preventing arrhythmias of a non-reentrant nature, but may be relatively ineffective in preventing reentrant ventricular tachycardia or ventricular fibrillation. |
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Authors:
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J Lynch; D Montgomery; A Ventura; D Wilber; B R Lucchesi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 36 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-06-09 Completed Date: 1986-06-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 475-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General Animals Anti-Arrhythmia Agents / pharmacology* Arrhythmias, Cardiac / drug therapy Coronary Circulation / drug effects Coronary Disease / drug therapy Dogs Electric Stimulation Electrocardiography Heart Ventricles / drug effects, physiopathology Male Myocardial Infarction / drug therapy Phenytoin / administration & dosage, analogs & derivatives*, pharmacology Tachycardia / drug therapy |
| Grant Support | |
ID/Acronym/Agency:
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HL-05806-23/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 56079-80-2/ropitoin hydrochloride; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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