Document Detail

Antiarrhythmic therapy in elderly persons: a device-based approach.
MedLine Citation:
PMID:  15654147     Owner:  NLM     Status:  MEDLINE    
The management of ventricular arrhythmias in elderly persons has undergone a dramatic evolution over the past 10 years. Although life-threatening arrhythmias in elderly persons have been traditionally managed with a variety of pharmacologic agents, this population presents special challenges from pharmacokinetic and pharmacodynamic perspectives. Drug absorption, distribution, metabolism, and efficacy are often altered in elderly patients, resulting in a substantially narrowed therapeutic window. Nonpharmacologic therapy for ventricular arrhythmias has the advantage of not being subject to changes in metabolism, and due to recent technological advances in transvenous lead design as well as improved programming flexibility and reduction in device size, device-based therapy for malignant ventricular arrhythmias has become more attractive for use in elderly patients. Several recent studies have suggested that device-based therapy provides superior protection from malignant arrhythmias for both primary and secondary prevention indications. The majority of these studies suggest that the benefits of device-based therapy are conferred to patients independent of age. In addition, the complication rate of such therapy appears to be independent of age.
Kevin J Ferrick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of geriatric cardiology     Volume:  14     ISSN:  1076-7460     ISO Abbreviation:  Am J Geriatr Cardiol     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-01-17     Completed Date:  2005-05-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9215283     Medline TA:  Am J Geriatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10-3; quiz 14     Citation Subset:  IM    
Arrhythmia Service, Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467-2401, USA.
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MeSH Terms
Arrhythmias, Cardiac / therapy*
Cardiac Pacing, Artificial*
Defibrillators, Implantable*
Equipment Design

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