Document Detail


Antiarrhythmic properties of ranolazine--from bench to bedside.
MedLine Citation:
PMID:  22916846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Pharmacological management of cardiac arrhythmias is limited by the reduced availability of safe and effective antiarrhythmic agents.
AREAS COVERED: Ranolazine is an agent currently used for the treatment of angina, which inhibits transmembrane ionic currents involved in several phases of the action potential in both the atrial and the ventricular cells. Due to its mechanism of action, ranolazine has been shown to exhibit antiarrhythmic properties that have been validated in the experimental models. This article recapitulates the mechanism of antiarrhythmic action of ranolazine, the existing clinical data, and the ongoing relevant clinical trials.
EXPERT OPINION: The combination of the antiischemic properties of ranolazine with its antiarrhythmic potency and minimal proarrhythmia provides a promising background that could expand its therapeutic role in the management of atrial fibrillation and ventricular tachyarrhythmias. Data derived from adequately powered randomized clinical trials will determine whether the door to a new indication will open for ranolazine in the near future.
Authors:
Stylianos Tzeis; George Andrikopoulos
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Publication Detail:
Type:  Journal Article     Date:  2012-08-23
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  21     ISSN:  1744-7658     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-12     Completed Date:  2013-03-08     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  1733-41     Citation Subset:  IM    
Affiliation:
Henry Dunant Hospital, Cardiology Department, Stylianos Tzeis MD, 107, Mesogion str, Athens, Greece. stzeis@otenet.gr
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MeSH Terms
Descriptor/Qualifier:
Acetanilides / adverse effects,  pharmacology*,  therapeutic use
Anti-Arrhythmia Agents / adverse effects,  pharmacology*,  therapeutic use
Arrhythmias, Cardiac / drug therapy*,  physiopathology
Atrial Fibrillation / drug therapy,  physiopathology
Clinical Trials as Topic
Humans
Piperazines / adverse effects,  pharmacology*,  therapeutic use
Tachycardia, Ventricular / drug therapy,  physiopathology
Chemical
Reg. No./Substance:
0/Acetanilides; 0/Anti-Arrhythmia Agents; 0/Piperazines; 110445-25-5/ranolazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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