| Antiarrhythmic, metabolic and hemodynamic effects of Org 6001 (3alpha-amino-5alpha-androstan-2beta-ol-17-one-hydrochloride) after coronary flow reduction in pigs. | |
| | |
MedLine Citation:
|
PMID: 633069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The antiarrhythmic activity of the aminosteroid Org 6001 was investigated in young pigs (20-28 kg). Ventricular arrhythmias were induced by restriction of the flow in the left anterior descending coronary artery (LAD) to 25% of its control value during a period of 30 minutes. Nine out of 30 control animals died in this period due to ventricular fibrillation. None of the 19 animals treated with Org 6001 (5-10 mg/kg) or the 12 animals treated with lidocaine (2.75-3.50 mg/kg) fibrillated. Moreover, the number of premature ventricular beats was greatly reduced in pretreated groups compared with the untreated group (P less than .001). The first derivative of left ventricular pressure decreased with 25% (P less than 0.001) after administration of Org 6001. However, during 30 minutes of LAD flow reduction to 25% of control, the adverse effects of Org 6001 were less than those of lidocaine. Myocardial lactate production indicated some delay in onset of ischemia. However, there was no indication that this beneficial effect was long-lasting. When after 30 minutes of LAD flow reduction to 25% of control, the LAD was completely occluded between its second and third branch, all untreated animals fibrillated within 120 minutes, whereas 4 of the 19 animals treated with Org 6001 and 3 of the 12 treated with lidocaine survived. It is concluded that Org 6001 has antiarrhythmic properties in the ischemic pig heart which compare favorably with those of lidocaine. |
| | |
Authors:
|
P D Verdouw; H C Schamhardt; W J Remme; J W De Jong |
Related Documents
:
|
1149509 - An electrocardiographic pattern of acute myocardial infarction associated with excessiv... 7006619 - Comparative study of the effects of penbutolol and propranolol in the treatment of angi... 639229 - Reduction of enzyme levels by propranolol after acute myocardial infarction. 975619 - Plasma propranolol concentration in patients with angina and acute myocardial infarction. 2142279 - The effect of propranolol, verapamil and dantrolene treatment on cardiac hypertrophy, e... 7212479 - Increased alpha-1-acid glycoprotein and lidocaine disposition in myocardial infarction. 12860869 - Risk factors for pacemaker implantation following aortic valve replacement: a single ce... 17629389 - Spontaneous defibrillation after cessation of resuscitation in out-of-hospital cardiac ... 14962479 - Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of pharmacology and experimental therapeutics Volume: 204 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1978 Mar |
Date Detail:
|
Created Date: 1978-05-24 Completed Date: 1978-05-24 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 634-44 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
17-Ketosteroids
/
pharmacology Androstanes / pharmacology* Animals Anti-Arrhythmia Agents* Blood Gas Analysis Coronary Disease / metabolism, physiopathology* Hemodynamics / drug effects* Lactates / metabolism Lidocaine / pharmacology Myocardium / metabolism* Potassium / metabolism Swine |
| Chemical | |
Reg. No./Substance:
|
0/17-Ketosteroids; 0/Androstanes; 0/Anti-Arrhythmia Agents; 0/Lactates; 137-58-6/Lidocaine; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intravenous self-administration of drugs in rats.
Next Document: Effects of some coronary vasodilator drugs on collateral hemodynamics after chronic myocardial ische...