| Antiarrhythmic and hypotensive activities of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one (MG-1(R,S)) and its enantiomers. | |
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MedLine Citation:
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PMID: 21602601 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The compound MG-1(R,S), (1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, and its enantiomers were tested for electrocardiographic, antiarrhythmic and hypotensive activities. The racemic mixture (MG-1(R,S)) and its S-enantiomer significantly decreased systolic and diastolic blood pressure and possessed antiarrhythmic activity. The S-enantiomer displayed the greatest effect. The R-enantiomer did not show antiarrhythmic or hypotensive activity. The results suggest that the antiarrhythmic and hypotensive effects of these compounds are related to their adrenolytic properties. |
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Authors:
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Jacek Sapa; Barbara Filipek; Leszek Nowiński |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pharmacological reports : PR Volume: 63 ISSN: 1734-1140 ISO Abbreviation: Pharmacol Rep Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-09-16 Revised Date: 2011-11-28 |
Medline Journal Info:
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Nlm Unique ID: 101234999 Medline TA: Pharmacol Rep Country: Poland |
Other Details:
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Languages: eng Pagination: 455-63 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, Laboratory of Pharmacological Screening, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Kraków, Poland. jaceksapa@interia.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents / chemistry, pharmacology* Antihypertensive Agents / chemistry, pharmacology* Arrhythmias, Cardiac / drug therapy*, physiopathology Blood Pressure / drug effects Disease Models, Animal Electrocardiography Male Pyrrolidinones / chemistry, pharmacology* Rats Rats, Wistar Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/1-(2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl)pyrrolidin-2-one; 0/Anti-Arrhythmia Agents; 0/Antihypertensive Agents; 0/Pyrrolidinones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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