Document Detail


Antiarrhythmic and hypotensive activities of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one (MG-1(R,S)) and its enantiomers.
MedLine Citation:
PMID:  21602601     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The compound MG-1(R,S), (1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, and its enantiomers were tested for electrocardiographic, antiarrhythmic and hypotensive activities. The racemic mixture (MG-1(R,S)) and its S-enantiomer significantly decreased systolic and diastolic blood pressure and possessed antiarrhythmic activity. The S-enantiomer displayed the greatest effect. The R-enantiomer did not show antiarrhythmic or hypotensive activity. The results suggest that the antiarrhythmic and hypotensive effects of these compounds are related to their adrenolytic properties.
Authors:
Jacek Sapa; Barbara Filipek; Leszek Nowiński
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  63     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:  2011  
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-09-16     Revised Date:  2011-11-28    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  455-63     Citation Subset:  IM    
Affiliation:
Department of Pharmacodynamics, Laboratory of Pharmacological Screening, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9, PL 30-688 Kraków, Poland. jaceksapa@interia.pl
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Arrhythmia Agents / chemistry,  pharmacology*
Antihypertensive Agents / chemistry,  pharmacology*
Arrhythmias, Cardiac / drug therapy*,  physiopathology
Blood Pressure / drug effects
Disease Models, Animal
Electrocardiography
Male
Pyrrolidinones / chemistry,  pharmacology*
Rats
Rats, Wistar
Stereoisomerism
Chemical
Reg. No./Substance:
0/1-(2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl)pyrrolidin-2-one; 0/Anti-Arrhythmia Agents; 0/Antihypertensive Agents; 0/Pyrrolidinones

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