Document Detail


Antiarrhythmic, haemodynamic and metabolic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one hydrochloride in greyhounds following acute coronary artery ligation.
MedLine Citation:
PMID:  1133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 The antiarrhythmic, haemodynamic and metabolic effects of a new amino steroid, ORG6001, have been investigated in experimental acute myocardial infarction in anaesthetized greyhounds. 2 ORG6001 administered either intravenously (2-10 mg/kg) or orally (50 mg/kg) significantly reduced the incidence of ventricular ectopic beats in the first 30 min after ligation of the left anterior descending coronary artery. 3 In dogs pretreated with ORG6001, metabolic changes indicative of myocardial ischaemia (lactate production and potassium efflux) were less marked than those occurring in control animals. 4 Antiarrhythmic doses of ORG6001 caused only minimal transient haemodynamic effects. 5 These results suggest that ORG6001 may possess distinct advantages over presently-used antiarrhythmic drugs in the prevention and treatment of the early arrhythmias which occur after myocardial infarction.
Authors:
R J Marshall; J R Parratt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  55     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-03-30     Completed Date:  1976-03-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  359-68     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
17-Ketosteroids / pharmacology
Androstanes / pharmacology*
Animals
Anti-Arrhythmia Agents / pharmacology*
Blood Pressure / drug effects
Carbon Dioxide / metabolism
Coronary Vessels / physiology*
Dogs
Female
Heart / drug effects
Hemodynamics / drug effects*
Hydrogen-Ion Concentration
Lidocaine / pharmacology
Male
Myocardium / metabolism
Oxygen Consumption / drug effects*
Time Factors
Chemical
Reg. No./Substance:
0/17-Ketosteroids; 0/Androstanes; 0/Anti-Arrhythmia Agents; 124-38-9/Carbon Dioxide; 137-58-6/Lidocaine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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