Document Detail


Antiarrhythmic efficacy of ethacizine assessed by programmed electrical stimulation in patients with ventricular tachycardia.
MedLine Citation:
PMID:  1279614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of ethacizine, a Class Ic drug, was assessed by programmed electrical stimulation (PES), delivering single, double, and triple extrastimuli at paced drives of 100 and 140 beats/min from two right ventricular sites (apex and outflow tract) in 38 patients with recurrent sustained ventricular tachycardia (VT). Underlying disease was coronary artery disease (CAD) in 26 (group I) and other conditions in 12 patients (group II; hypertrophic cardiomyopathy in 7, mitral valve prolapse in 1, and no apparent heart disease in 4). In the baseline study VT was induced in all patients. After a single intravenous dose (0.6-0.7 mg/kg) of ethacizine, VT was still inducible in six patients in group I and seven patients in group II. Ethacizine was administered on a long-term basis to all patients in a dose of 200-400 mg per day. All but one CAD patient remained free of recurrences after a mean follow-up of 16.5 (range 3-22) months, while there were recurrences in six of 12 patients in group II. We conclude that: (1) ethacizine appears to be effective in the treatment of VT in CAD patients; (2) the study demonstrates the clinical utility of PES in the management of VT, although some patients in whom VT remains inducible on ethacizine may have good clinical outcome; and (3) the efficacy of ethacizine in other forms of heart disease remains to be studied.
Authors:
J Kaik; V Kaik; M Kiitam
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  15     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-16     Completed Date:  1992-12-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2134-7     Citation Subset:  IM    
Affiliation:
Department of Cardiac Arrhythmias, Estonian Institute of Cardiology, Tallinn.
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MeSH Terms
Descriptor/Qualifier:
Anti-Arrhythmia Agents / therapeutic use*
Cardiac Pacing, Artificial*
Female
Follow-Up Studies
Humans
Male
Middle Aged
Phenothiazines / therapeutic use*
Tachycardia, Ventricular / diagnosis,  drug therapy*,  epidemiology
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Phenothiazines; 33414-33-4/ethacizine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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