| Antiarrhythmic effect of a new class 1 antiarrhythmic drug, AN-132, on ventricular arrhythmias in beagles. | |
| | |
MedLine Citation:
|
PMID: 2488108 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Using two-stage coronary-ligation-, digitalis- and adrenaline-induced ventricular arrhythmias in beagles, antiarrhythmic effects of AN-132 were examined, and the minimum effective plasma concentration for each arrhythmia model was determined. AN-132 suppressed all the arrhythmias, and the minimum effective plasma concentrations for arrhythmias induced by 24-hour coronary ligation, 48-hour coronary ligation, digitalis, and adrenaline were 3.4-4.6, 1.5-2.3, 0.83, and 9.3 micrograms/ml, respectively. The concentration for adrenaline-induced arrhythmia was significantly higher than that of 24-hour coronary ligation arrhythmia, and it was also higher than that of digitalis arrhythmia. This pharmacologic profile is similar to those of pirmenol and mexiletine. Since AN-132 had no deleterious effects on the hemodynamics and the central nervous system, it may become a clinically useful antiarrhythmic drug. |
| | |
Authors:
|
K Hashimoto; K Watanabe; H Mitsuhashi |
Related Documents
:
|
18388358 - Incidence and prognosis of sustained arrhythmias in critically ill patients. 16797868 - Elimination of cardiac arrhythmias using oral taurine with l-arginine with case histori... 872158 - Free fatty acids and arrhythmias following acute coronary artery occlusion in pigs. 7502998 - Pet ownership, social support, and one-year survival after acute myocardial infarction ... 16368338 - Microwave ablation for atrial fibrillation: dose-response curves in the cardioplegia-ar... 7788608 - Perforation of the small bowel: a case report. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 3 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 1989 Oct |
Date Detail:
|
Created Date: 1991-04-23 Completed Date: 1991-04-23 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 683-9 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Yamanashi Medical College, Tamaho-cho, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anilides
/
blood,
pharmacology* Animals Anti-Arrhythmia Agents / pharmacology* Arrhythmias, Cardiac / drug therapy* Coronary Vessels / physiology, surgery Digitalis Dogs Dose-Response Relationship, Drug Epinephrine / toxicity Ethylenediamines / blood, pharmacology* Female Ligation Male Plants, Medicinal Plants, Toxic Tachycardia / drug therapy* Ventricular Function / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide, diphosphoric acid; 0/Anilides; 0/Anti-Arrhythmia Agents; 0/Ethylenediamines; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibition of calmodulin and protein kinase C by amiodarone and other class III antiarrhythmic agent...
Next Document: Bepridil: a pharmacological reappraisal of its potential beneficial effects in angina and tissue pro...