Document Detail


Antiarrhythmic effect of caffeic acid phenethyl ester (CAPE) on myocardial ischemia/reperfusion injury in rats.
MedLine Citation:
PMID:  16098504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The present study was designed to determine the antiarrhythmic effect of caffeic acid phenethyl ester (CAPE), an active component of propolis, which exhibits antioxidant properties, in rats subjected to myocardial ischemia and ischemia-reperfusion (I/R) injury. DESIGN AND METHODS: Rats were subjected to 30 min coronary artery occlusion for evaluating the effect of CAPE on the myocardial ischemia injury. While in the myocardial I/R injury study, the coronary artery was ligated for a 5-min period of ischemia followed by a 30-min period of reperfusion. Animals were pretreated with or without CAPE before coronary artery ligation and the severity of myocardial ischemia- and I/R-induced arrhythmias and mortality were compared. RESULTS: Pretreatment of CAPE (0.1 and 1 microg/kg) not only reduced both the incidence and duration of ventricular tachycardia (VT) and ventricular fibrillation (VF) but also decreased the mortality during the myocardial ischemia and I/R injury period. CONCLUSIONS: Our results suggest that CAPE is a potent antiarrhythmic agent with cardioprotective effects in myocardial ischemia and I/R injury rats.
Authors:
Shiang-Suo Huang; Sheng-Ming Liu; Su-Man Lin; Pei-Hu Liao; Ruey-Hseng Lin; Yu-Chia Chen; Chun-Lien Chih; Shen-Kou Tsai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical biochemistry     Volume:  38     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-19     Completed Date:  2006-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  943-7     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Arrhythmia Agents / therapeutic use*
Caffeic Acids / therapeutic use*
Male
Myocardial Reperfusion Injury / drug therapy*
Phenylethyl Alcohol / analogs & derivatives*,  therapeutic use
Rats
Rats, Sprague-Dawley
Tachycardia, Ventricular / drug therapy
Ventricular Fibrillation / drug therapy
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Caffeic Acids; 104594-70-9/caffeic acid phenethyl ester; 60-12-8/Phenylethyl Alcohol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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