Document Detail

Antiarrhythmic and cardiovascular profiles of the fused indole compound (3aR,12R,12aR,12bS)-12-amino-2,3,3a,4,11,12,12a,12b-octahydro-10-hydrox yisoquino [2,1,8-lma]carbazol-5(1H)-one hydrochloride 1.5 hydrate.
MedLine Citation:
PMID:  1810258     Owner:  NLM     Status:  MEDLINE    
Antiarrhythmic and cardiovascular profiles of a fused indole compound, (3aR,12R,12aR,12bS)-12-amino-2,3,3a,4,11,12,12a,12b -octahydro- 10-hydroxyisoquino [2,1,8-lma]carbazol-5(1H)-one hydrochloride 1.5 hydrate (RS-2135, CAS 133775-36-7), were investigated in anesthetized dogs. Class I antiarrhythmic agents such as disopyramide, lidocaine, mexiletine and flecainide were used as reference compounds. RS-2135 exerted more potent antiarrhythmic activity than reference compounds against ouabain-induced arrhythmias in dogs. The onset of action was slow, but the duration of action was longer than with the other compounds tested. The agent suppressed the conduction in the atrium, A-V node and ventricle more markedly than the reference compounds. RS-2135, however, did not change blood pressure and heart rate at a dose 5 times the dose for antiarrhythmic activity and decreased cardiac contractility to a lesser extent than the reference compounds.
R Yorikane; H Mizuno; Y Itoh; H Koike; S Miyake; H Shiga; S Kumakura; M Fukami; Y Shimoji; T Hashimoto
Related Documents :
6867008 - Acute cardiovascular response to a single large intravenous dose of methylprednisolone ...
2417048 - Central alpha-adrenergic agonists in chronic heart failure and ischemic heart disease.
23532678 - Urethral pressure reflectometry during intra-abdominal pressure increase-an improved te...
635588 - 3-methoxy-4-hydroxyphenylglycol in cerebrospinal fluid and vanillylmandelic acid in uri...
19449968 - Parametric finite element analysis of physical stimuli resulting from mechanical stimul...
462368 - Effects of iris pigmentation on response of ocular pressure to timolol.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  41     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-05-26     Completed Date:  1992-05-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1130-6     Citation Subset:  IM    
Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Arrhythmia Agents / pharmacology*
Arrhythmias, Cardiac / chemically induced,  prevention & control
Carbazoles / pharmacology*
Disopyramide / pharmacology
Flecainide / pharmacology
Heart / drug effects
Heart Conduction System / drug effects
Hemodynamics / drug effects*
Isoquinolines / pharmacology*
Lidocaine / pharmacology
Mexiletine / pharmacology
Mice, Inbred ICR
Myocardial Contraction / drug effects
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Carbazoles; 0/Isoquinolines; 133775-36-7/RS 2135; 137-58-6/Lidocaine; 31828-71-4/Mexiletine; 3737-09-5/Disopyramide; 54143-55-4/Flecainide; 630-60-4/Ouabain; 67-66-3/Chloroform

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Central analgesic effects of acetylsalicylic acid in healthy men.
Next Document:  DNA single strand-breaks in human lymphocytes after therapy with antirheumatic drugs.