Document Detail

Antiarrhythmic benefits of dual chamber stimulation with rate-response in patients with paroxysmal atrial fibrillation and chronotropic incompetence: a prospective, multicentre study.
MedLine Citation:
PMID:  11220558     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: While the haemodynamic benefits of DDDR pacing compared with DDD pacing in patients with brady-tachy syndrome and chronotropic incompetence (CI) are well demonstrated, the antiarrhythmic advantage is controversial and so far not clearly demonstrated. AIM: We have performed a prospective, randomized, multicentre study to evaluate the efficacy of DDDR and DDD pacing modes in preventing paroxysmal atrial fibrillation (PAF) episodes in patients with brady-tachy syndrome and CI. METHODS AND RESULTS: Seventy-eight patients were included in the study. All patients had a dual chamber pacemaker implanted and were randomly programmed to DDD or DDDR with a cross over (DDD --> DDDR or vice versa) at 3 months. The final evaluation was performed at 6 months by means of two self-administered symptom questionnaires to evaluate activity. Symptoms of palpitations were analysed and scored. The patients were less symptomatic with the DDDR mode. The number of mode-switch activations compared with symptomatic episodes of PAF confirmed the high rate of asymptomatic PAF episodes in patients with brady-tachy syndrome. We conclude that in a small but well defined population of patients affected by sick sinus syndrome with CI and severely symptomatic PAF, DDDR pacing compared with DDD pacing may offer an additional antiarrhythmic benefit and should be considered the primary mode of pacing.
F Bellocci; A Spampinato; R Ricci; A Puglisi; A Capucci; P Dini; G Boriani; G Botto; A Curnis; P V Moracchini; G Nicotra; F Lisi; P Nigro
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  1     ISSN:  1099-5129     ISO Abbreviation:  Europace     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2001-02-23     Completed Date:  2001-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-5     Citation Subset:  IM    
Clinica Villa Tiberia, Rome, Italy.
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MeSH Terms
Atrial Fibrillation / prevention & control*
Cardiac Pacing, Artificial / methods*
Middle Aged
Prospective Studies
Sick Sinus Syndrome / therapy*
Comment In:
Europace. 1999 Oct;1(4):211-2   [PMID:  11220555 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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