Document Detail


Antiarrhythmic benefits of dual chamber stimulation with rate-response in patients with paroxysmal atrial fibrillation and chronotropic incompetence: a prospective, multicentre study.
MedLine Citation:
PMID:  11220558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: While the haemodynamic benefits of DDDR pacing compared with DDD pacing in patients with brady-tachy syndrome and chronotropic incompetence (CI) are well demonstrated, the antiarrhythmic advantage is controversial and so far not clearly demonstrated. AIM: We have performed a prospective, randomized, multicentre study to evaluate the efficacy of DDDR and DDD pacing modes in preventing paroxysmal atrial fibrillation (PAF) episodes in patients with brady-tachy syndrome and CI. METHODS AND RESULTS: Seventy-eight patients were included in the study. All patients had a dual chamber pacemaker implanted and were randomly programmed to DDD or DDDR with a cross over (DDD --> DDDR or vice versa) at 3 months. The final evaluation was performed at 6 months by means of two self-administered symptom questionnaires to evaluate activity. Symptoms of palpitations were analysed and scored. The patients were less symptomatic with the DDDR mode. The number of mode-switch activations compared with symptomatic episodes of PAF confirmed the high rate of asymptomatic PAF episodes in patients with brady-tachy syndrome. We conclude that in a small but well defined population of patients affected by sick sinus syndrome with CI and severely symptomatic PAF, DDDR pacing compared with DDD pacing may offer an additional antiarrhythmic benefit and should be considered the primary mode of pacing.
Authors:
F Bellocci; A Spampinato; R Ricci; A Puglisi; A Capucci; P Dini; G Boriani; G Botto; A Curnis; P V Moracchini; G Nicotra; F Lisi; P Nigro
Related Documents :
8889658 - Clinical and histopathological studies in children with supraventricular tachycardia.
2463528 - Transesophageal programmed atrial pacing as a method of selecting patients with sick si...
793368 - Electrophysiologic effects of atropine on sinus node and atrium in patients with sinus ...
1149548 - Electrophysiologic studies in a patient with atrial flutter and 1:1 atrioventricular co...
21426888 - Parenteral vitamin b12 in macrocytic hemodialysis patients reduced mma levels but did n...
22783398 - Correlation of histone methyl marks with circulating nucleosomes in blood plasma of can...
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  1     ISSN:  1099-5129     ISO Abbreviation:  Europace     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2001-02-23     Completed Date:  2001-03-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-5     Citation Subset:  IM    
Affiliation:
Clinica Villa Tiberia, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Atrial Fibrillation / prevention & control*
Cardiac Pacing, Artificial / methods*
Female
Humans
Male
Middle Aged
Prospective Studies
Sick Sinus Syndrome / therapy*
Comments/Corrections
Comment In:
Europace. 1999 Oct;1(4):211-2   [PMID:  11220555 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Positive head-up tilt table test in patients with the long QT syndrome.
Next Document:  An epidemiological study of symptomatic paroxysmal atrial fibrillation in northwest Greece.