Document Detail

Antiapoptotic effect of heat adaptation in cultured cells.
MedLine Citation:
PMID:  12802413     Owner:  NLM     Status:  MEDLINE    
Heat adaptation of cultured rat cardiomyoblasts and mouse myoblasts protected these cells from damage produced by staurosporine and attenuated metabolic disturbances. Heat adaptation inhibited apoptotic, but not necrotic cell death. The mechanism of antiapoptotic adaptive protection was not associated with prevention of mitochondrial depolarization, because heat adaptation not only induced depolarization of mitochondria, but also intensified this process under conditions of staurosporine-induced damage.
E A Monastyrskaya; M R Duchen; L V Andreeva; F Viegant; E B Manukhina; I Yu Malyshev
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  135     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-06-12     Completed Date:  2004-05-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  IM    
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
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MeSH Terms
Adaptation, Physiological*
Apoptosis / physiology*
Cell Line
Enzyme Inhibitors / metabolism
Hot Temperature*
Membrane Potentials / physiology
Mitochondria / metabolism
Myoblasts / cytology,  metabolism*
Myocytes, Cardiac / cytology,  metabolism*
Staurosporine / metabolism
Reg. No./Substance:
0/Enzyme Inhibitors; 62996-74-1/Staurosporine

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