Document Detail

Antianxiety effects of lorazepam in patients with cardiovascular symptomatology.
MedLine Citation:
PMID:  30766     Owner:  NLM     Status:  MEDLINE    
Lorazepam was administered to 38 patients with moderate to severe anxiety associated with cardiovascular symptomatology. A comparable group of patients on placebo (35) served as controls in this 4-week study. Average dosage was 3 mg/day given as 2 mg in the evening and 1 mg in the morning. The Global response, Hamilton Anxiety Rating Scale scores, and 35-Item Self-Rating Scale scores showed lorazepam to be significantly more effective in relieving anxiety than placebo, both clinically and statistically. Adverse reactions were transient and tolerable, and were reported in only 2 patients on lorazepam.
S Finkel
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  39     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-01-15     Completed Date:  1979-01-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Anti-Anxiety Agents / therapeutic use*
Anxiety Disorders / drug therapy*,  etiology
Cardiovascular Diseases / psychology*
Double-Blind Method
Lorazepam / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Psychiatric Status Rating Scales
Time Factors
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Placebos; 846-49-1/Lorazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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