| Antiangiogenic properties of an unusual benzo[k,l]xanthene lignan derived from CAPE (Caffeic Acid Phenethyl Ester). | |
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MedLine Citation:
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PMID: 20924642 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Angiogenesis is normally a highly regulated process that occurs during development, reproduction, and wound repair. However, angiogenesis can also become a fundamental pathogenic process in cancer and several other diseases. To date, the synthesis of angiogenesis inhibitors has been researched in several ways also starting from bioactive plant compounds. In the present study, we tested both in an angiogenesis bioassay and in ovarian cell culture, the potential antiangiogenic effect of a natural-derived benzo[k,l]xanthene lignan (5). This unusual compound was synthesized through the biomimetic dimerization of CAPE (Caffeic Acid Phenetyl Ester), a bioactive component of honeybee propolis. The lignan showed a significant, dose-related inhibitory effect on new vessel growth in the angiogenesis bioassay and it inhibited Vascular Endothelial Growth Factor secretion in ovarian cell culture. Therefore, we indicate the natural-derived benzo[k,l]xanthene lignan 5 as a potential new angiogenesis inhibitor. |
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Authors:
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Giuseppina Basini; Laura Baioni; Simona Bussolati; Francesca Grasselli; Carmelo Daquino; Carmela Spatafora; Corrado Tringali |
Publication Detail:
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Type: Journal Article Date: 2010-10-06 |
Journal Detail:
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Title: Investigational new drugs Volume: 30 ISSN: 1573-0646 ISO Abbreviation: Invest New Drugs Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309330 Medline TA: Invest New Drugs Country: United States |
Other Details:
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Languages: eng Pagination: 186-90 Citation Subset: IM |
Affiliation:
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Dipartimento di Produzioni Animali, Biotecnologie Veterinarie, Qualità e Sicurezza degli Alimenti-Sezione di Fisiologia Veterinaria, Università degli Studi di Parma, Via del Taglio 10, 43126, Parma, Italy, basini@unipr.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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