Document Detail

Antiangiogenic effect of 2-benzoyl-phenoxy acetamide in EAT cell is mediated by HIF-1alpha and down regulation of VEGF of in-vivo.
MedLine Citation:
PMID:  16598437     Owner:  NLM     Status:  MEDLINE    
Benzophenones and its analogues are known for wide range of biological properties. Synthetic benzophenone analogue 2-benzoyl -phenoxy acetamide (BP-1) is proven to be potent antitumor and proapoptotic activity against EAT cells in-vivo. In the present report, we studied the antiangiogenic effect of BP-1 in EAT cells induced angiogenesis. Treatment with BP-1 in-vivo was demonstrated by the down regulation of the secretion of VEGF from EAT cells and inhibition of blood vessels formation indicating the potential angioinhibitory effect of BP-1 in EAT cells. HIF-1alpha protein, a transcription factor known to be key a regulator in hypoxia-induced angiogenesis was also down regulated by BP-1. Our findings indicated that, HIF-1alpha nuclear sequestration is repressed by BP-1 through inhibition of nuclear translocation. We postulate that diminished HIF-1alpha nuclear presence and activity in BP-1 treated EAT cells could be responsible for decreased VEGF expression and antiangiogenic effects.
B T Prabhakar; Shaukath Ara Khanum; S Shashikanth; Bharathi P Salimath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigational new drugs     Volume:  24     ISSN:  0167-6997     ISO Abbreviation:  Invest New Drugs     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-08-22     Completed Date:  2007-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309330     Medline TA:  Invest New Drugs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  471-8     Citation Subset:  IM    
Department of Studies in Applied Botany & Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India.
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MeSH Terms
Acetamides / pharmacology*
Angiogenesis Inhibitors / pharmacology*
Antineoplastic Agents / pharmacology*
Ascitic Fluid / chemistry
Carcinoma, Ehrlich Tumor / metabolism*
Cell Line, Tumor
Chick Embryo
Chorioallantoic Membrane / blood supply,  drug effects*
Hypoxia-Inducible Factor 1, alpha Subunit / drug effects*,  metabolism
Neovascularization, Pathologic / prevention & control*
Neovascularization, Physiologic / drug effects*
Peritoneum / blood supply,  drug effects*,  pathology
Protein Transport / drug effects
Vascular Endothelial Growth Factor A / metabolism*
Reg. No./Substance:
0/2-benzoyl-phenoxy acetamide; 0/Acetamides; 0/Angiogenesis Inhibitors; 0/Antineoplastic Agents; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 0/Vascular Endothelial Growth Factor A

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