| Antianginal, hemodynamic and coronary vascular effects of captopril in stable angina pectoris. | |
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MedLine Citation:
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PMID: 2196774 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A pilot study was performed to assess the short-term effects of intravenous captopril on anginal threshold and systemic and coronary hemodynamics in patients with stable angina pectoris. Twelve patients with documented coronary artery disease, stable angina pectoris and normal left ventricular function were studied by an incremental atrial pacing stress test before and after intravenous captopril (n = 8) or placebo (n = 4). There were no significant differences in the extent of coronary disease or left ventricular function between the 2 groups and resting plasma-renin levels were normal. Captopril increased the time to angina (14 +/- 4 to 9 +/- 5 minutes, p less than 0.05), increased heart rate at development of angina (126 +/- 7 to 142 +/- 7 beats/min, p less than 0.05) and tended to increase coronary blood flow (229 +/- 154 to 296 +/- 259 ml/min, p = 0.11) and decrease coronary vascular resistance (53 +/- 10 to 47 +/- 3 dynes s cm-5/1,000, p = 0.11) at peak stress without alteration in systemic hemodynamics. No significant changes were seen after placebo administration. Therefore, intravenous captopril appears to cause a short-term increase of coronary vascular reserve, and anginal threshold in patients with chronic stable angina. This effect appears to be independent of inhibition of the systemic renin-angiotensin system or systemic hemodynamic changes. |
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Authors:
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H Ikram; C J Low; T Shirlaw; C M Webb; A M Richards; I G Crozier |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 66 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1990-08-21 Completed Date: 1990-08-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 164-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Princess Margaret Hospital, Christchurch, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
/
blood,
drug therapy*,
physiopathology Blood Pressure / drug effects Captopril / therapeutic use* Cardiac Output / drug effects Coronary Circulation / drug effects Exercise Test Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Lactates / blood Lactic Acid Male Middle Aged Oxygen / blood Pilot Projects Pulmonary Artery / physiopathology Renin / blood Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 50-21-5/Lactic Acid; 62571-86-2/Captopril; 7782-44-7/Oxygen; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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