Document Detail


Antianginal, hemodynamic and coronary vascular effects of captopril in stable angina pectoris.
MedLine Citation:
PMID:  2196774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A pilot study was performed to assess the short-term effects of intravenous captopril on anginal threshold and systemic and coronary hemodynamics in patients with stable angina pectoris. Twelve patients with documented coronary artery disease, stable angina pectoris and normal left ventricular function were studied by an incremental atrial pacing stress test before and after intravenous captopril (n = 8) or placebo (n = 4). There were no significant differences in the extent of coronary disease or left ventricular function between the 2 groups and resting plasma-renin levels were normal. Captopril increased the time to angina (14 +/- 4 to 9 +/- 5 minutes, p less than 0.05), increased heart rate at development of angina (126 +/- 7 to 142 +/- 7 beats/min, p less than 0.05) and tended to increase coronary blood flow (229 +/- 154 to 296 +/- 259 ml/min, p = 0.11) and decrease coronary vascular resistance (53 +/- 10 to 47 +/- 3 dynes s cm-5/1,000, p = 0.11) at peak stress without alteration in systemic hemodynamics. No significant changes were seen after placebo administration. Therefore, intravenous captopril appears to cause a short-term increase of coronary vascular reserve, and anginal threshold in patients with chronic stable angina. This effect appears to be independent of inhibition of the systemic renin-angiotensin system or systemic hemodynamic changes.
Authors:
H Ikram; C J Low; T Shirlaw; C M Webb; A M Richards; I G Crozier
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  66     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-21     Completed Date:  1990-08-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  164-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Princess Margaret Hospital, Christchurch, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / blood,  drug therapy*,  physiopathology
Blood Pressure / drug effects
Captopril / therapeutic use*
Cardiac Output / drug effects
Coronary Circulation / drug effects
Exercise Test
Female
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Lactates / blood
Lactic Acid
Male
Middle Aged
Oxygen / blood
Pilot Projects
Pulmonary Artery / physiopathology
Renin / blood
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; 62571-86-2/Captopril; 7782-44-7/Oxygen; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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