Document Detail

Antianginal drugs and relationship between epicardial ST segment depression and moderate regional myocardial blood flow reduction in experimental partial coronary artery occlusion.
MedLine Citation:
PMID:  2115398     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: The aim of the study was to determine whether moderate reduction in regional myocardial blood flow is related to epicardial ST segment depression and to the changes in grade and extent induced in this variable by antianginal drugs.
DESIGN: Blood flow through the anterior descending coronary artery was reduced to 25-30% of control in open chest dogs, using a cuff flow meter as a monitor, and glyceryl trinitrate, propranolol and nifedipine were infused 60 min later. Regional left ventricular blood flow was measured with 15 mu radioactive microspheres and electrocardiograms were recorded from the epicardial surface of the anterior left ventricular wall before and after administration of the drugs.
EXPERIMENTAL SUBJECTS: 20 adult male greyhounds were used, weighing 19-24 kg.
MEASUREMENTS AND RESULTS: Under control conditions there was a poor correlation between ST segment depression and regional flow. Neither glyceryl trinitrate nor nifedipine had any significant effect on ST segment depression in sites overlying zones with a flow range of 80-105% of normal flow. On the other hand, glyceryl trinitrate, but not nifedipine, decreased ST segment depression in sites overlying the central ischaemic zone (35-80% of control posterior wall flow). With propranolol, mean ST depression was decreased significantly in sites overlying the central ischaemic zone (35-80% of control flow), but not in sites overlying zones with flows ranging from 80-105% of normal. Propranolol reduced blood flow to all zones.
CONCLUSIONS: Epicardial ST segment depression is unreliable for the quantitative exploration of the grade and extent of myocardial ischaemia.
G B Timogiannakis; C B Kourouklis; E N Chlapoutakis; P K Toutouzas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  24     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-29     Completed Date:  1990-08-29     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  396-403     Citation Subset:  IM    
Department of Cardiology, Medical School, University of Athens-Hippokration Hospital, Greece.
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MeSH Terms
Angina Pectoris / drug therapy*
Coronary Circulation / drug effects*
Coronary Disease / physiopathology*
Electrocardiography / drug effects*
Nifedipine / pharmacology*
Nitroglycerin / pharmacology*
Pericardium / physiopathology
Propranolol / pharmacology*
Reg. No./Substance:
21829-25-4/Nifedipine; 525-66-6/Propranolol; 55-63-0/Nitroglycerin

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