Document Detail

Antiandrogenic effects of a flavonoid-rich fraction of Vitex negundo seeds: a histological and biochemical study in dogs.
MedLine Citation:
PMID:  2615438     Owner:  NLM     Status:  MEDLINE    
The ability of the flavonoid-rich fraction (5,7,3'-trihydroxy, 6,8,4'-trimethoxy flavones) of Vitex negundo seeds to antagonize the androgen action of exogenous testosterone propionate on the male reproductive system was studied in castrated prepubertal and intact adult dog. The flavonoid-rich fraction (F) was administered 10 mg/kg i.p. every other day either alone or in combination with testosterone propionate. The duration of treatment was 30 days in castrates and 60 days in intacts. Treatment with F caused disruption of the latter stages of spermatogenesis. The epididymides were devoid of spermatozoa. Protein, sialic acid and RNA contents of the testes and epididymides were reduced significantly while testicular cholesterol and phosphatase activity in testes and epididymides were elevated. Reduced androgen production was reflected in low levels of sialic acid in testes and epididymides. Castration alone brought about reduction in size and weight of the epididymides whereas castration followed by F treatment caused a reduction in the cellular heights of epididymides. Simultaneous administration of testosterone propionate to F-treated intact adult and castrated prepubertal dogs maintained the viability of spermatozoa, kept epididymal physiology relatively normal and significantly increased the cellular heights of epididymides.
S K Bhargava
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  27     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  327-39     Citation Subset:  IM    
Department of Zoology, University of Rajasthan, Jaipur, India.
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MeSH Terms
Androgen Antagonists*
Contraceptive Agents, Male
Epididymis / anatomy & histology,  drug effects,  metabolism
Flavonoids / pharmacology*
Organ Size / drug effects
Plant Extracts / pharmacology
Plants, Medicinal*
Spermatogenesis / drug effects
Testis / anatomy & histology,  drug effects,  metabolism
Testosterone / pharmacology
Reg. No./Substance:
0/Androgen Antagonists; 0/Contraceptive Agents, Male; 0/Flavonoids; 0/Plant Extracts; 58-22-0/Testosterone

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