Document Detail


Antiandrogenic effects of a flavonoid-rich fraction of Vitex negundo seeds: a histological and biochemical study in dogs.
MedLine Citation:
PMID:  2615438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of the flavonoid-rich fraction (5,7,3'-trihydroxy, 6,8,4'-trimethoxy flavones) of Vitex negundo seeds to antagonize the androgen action of exogenous testosterone propionate on the male reproductive system was studied in castrated prepubertal and intact adult dog. The flavonoid-rich fraction (F) was administered 10 mg/kg i.p. every other day either alone or in combination with testosterone propionate. The duration of treatment was 30 days in castrates and 60 days in intacts. Treatment with F caused disruption of the latter stages of spermatogenesis. The epididymides were devoid of spermatozoa. Protein, sialic acid and RNA contents of the testes and epididymides were reduced significantly while testicular cholesterol and phosphatase activity in testes and epididymides were elevated. Reduced androgen production was reflected in low levels of sialic acid in testes and epididymides. Castration alone brought about reduction in size and weight of the epididymides whereas castration followed by F treatment caused a reduction in the cellular heights of epididymides. Simultaneous administration of testosterone propionate to F-treated intact adult and castrated prepubertal dogs maintained the viability of spermatozoa, kept epididymal physiology relatively normal and significantly increased the cellular heights of epididymides.
Authors:
S K Bhargava
Related Documents :
807038 - Biochemical and immunological studies on salivary blood group substances.
814368 - Demonstration of carbohydrate structures in malignant melanoma tyrosinase.
4040398 - Blood group b-specific lectin of plecoglossus altivelis (ayu fish) eggs.
2411268 - Identification and isolation of an agglutinin from uterus of rats.
3119958 - Rapid changes in serum, plasma and erythrocyte lipid compositions, and serum transamina...
3620488 - The subcellular localization of phytanic acid oxidase in rat liver.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  27     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  327-39     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Rajasthan, Jaipur, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Androgen Antagonists*
Animals
Contraceptive Agents, Male
Dogs
Epididymis / anatomy & histology,  drug effects,  metabolism
Flavonoids / pharmacology*
Male
Orchiectomy
Organ Size / drug effects
Plant Extracts / pharmacology
Plants, Medicinal*
Seeds
Spermatogenesis / drug effects
Testis / anatomy & histology,  drug effects,  metabolism
Testosterone / pharmacology
Chemical
Reg. No./Substance:
0/Androgen Antagonists; 0/Contraceptive Agents, Male; 0/Flavonoids; 0/Plant Extracts; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Abortifacient potential for the epigeal parts of Peganum harmala.
Next Document:  Preliminary isolated organ studies using an aqueous extract of Clivia miniata leaves.