| Antiandrogen ICI 176,334 does not prevent development of androgen insensitivity in S115 mouse mammary tumour cells. | |
| | |
MedLine Citation:
|
PMID: 2214758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Many forms of endocrine therapy for steroid-sensitive tumours involve regimes of steroid agonist deprivation by administration of steroid antagonists. The partial or short-lived response to such therapy results from the inevitable progression of the tumour cells to a state of steroid insensitivity. Several cell culture systems have shown that steroid ablation results in loss of steroid sensitivity and we have used an in vitro model here to study the influence of steroid antagonists on this progression. Growth of androgen-responsive S115 mouse mammary tumour cells in the long-term absence of steroid results in a loss of androgen-sensitivity. We have studied here the effects of the pure antiandrogen ICI 176,334 on the growth of S115 cells and on their progression to steroid autonomy. Although a pure antiandrogen in its action on these cells with very low toxicity, it had no protective effect against loss of cellular or molecular androgen-responsive parameters. The clinical implications for endocrine therapy are discussed. |
| | |
Authors:
|
P D Darbre; R J King |
Related Documents
:
|
17078868 - Suppression of breast cancer cell growth by na+/h+ exchanger regulatory factor 1 (nherf1). 11807928 - Effects of butylated hydroxyanisole and butylated hydroxytoluene on dna adduct formatio... 7538448 - Different cytotoxic activity and intracellular fate of an anti-cd5-momordin immunotoxin... 19527768 - Wheat sprout extract-induced apoptosis in human cancer cells by proteasomes modulation. 6193128 - Regulation of mouse haptoglobin synthesis. 21686118 - Rho-guanine nucleotide exchange factors during development: force is nothing without co... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of steroid biochemistry Volume: 36 ISSN: 0022-4731 ISO Abbreviation: J. Steroid Biochem. Publication Date: 1990 Aug |
Date Detail:
|
Created Date: 1990-11-21 Completed Date: 1990-11-21 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0260125 Medline TA: J Steroid Biochem Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 385-9 Citation Subset: IM |
Affiliation:
|
Cellular Endocrinology Laboratory, Imperial Cancer Research Fund, London, England. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Androgen Antagonists
/
pharmacology* Anilides / pharmacology* Animals Blotting, Northern Cell Division / drug effects* Cell Line DNA, Neoplasm / genetics, isolation & purification Kinetics Mammary Neoplasms, Experimental Methylation Mice Nitriles RNA, Neoplasm / genetics, isolation & purification Restriction Mapping Testosterone / pharmacology* Tosyl Compounds |
| Chemical | |
Reg. No./Substance:
|
0/Androgen Antagonists; 0/Anilides; 0/DNA, Neoplasm; 0/Nitriles; 0/RNA, Neoplasm; 0/Tosyl Compounds; 58-22-0/Testosterone; 90357-06-5/bicalutamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: AV nodal reentrant tachycardia.
Next Document: Hydroxylated triphenylacrylonitriles adopt a unique orientation within the binding site of the estro...