Document Detail

Antiamoebic chemoprophylaxis using quinfamide in children: a comparative study.
MedLine Citation:
PMID:  12805964     Owner:  NLM     Status:  MEDLINE    
This study sought to examine whether the administration of quinfamide at 3- or 6-month intervals diminished the frequency of Entamoeba histolytica cysts in stool samples compared to controls. The prospective, longitudinal, randomized, single-blind study examined children from six primary schools in Celaya and Neutla, Guanajuato. Of the 1,524 students in these schools, we selected participants for the study as follows: Children were included in the study if their parents agreed in writing to the study and if the children demonstrated evidence of E. histolytica cysts after a parasitoscopic analysis by concentration (PSC) in three samples over consecutive days using Faust"s method. Those included in the study received a single 4.3-g/kg dose of quinfamide, and we performed PSC on days 5, 6, and 7 following dose administration to examine whether quinfamide had affected the presence of the cysts. The study participants who tested negative for cysts were divided into three groups: Group 1 had 102 patients who underwent quinfamide treatment and three CPS analyses after the 12 months of the study; Group 2 had 98 subjects who underwent the quinfamide treatment and three CPS analyses at months 3, 6, 9, and 12 after their entrance into the study; and Group 3 had 102 patients, who underwent the quinfamide treatment and series of three CPS analyses at months 6 and 12 of the study. All participants received the dose of quinfamide after providing stool samples and after a clinical gastrointestinal history was obtained. Further clinical gastrointestinal data were collected 5 days after the quintamide dose was administered. We used EpiInfo 6.0 for statistical analysis, calculating c2 and p values for the clinical data and the CPS data after the 12 months concluded. Of the initial samples of 1,524 subjects, 308 (20.2%) had Entamoebic cysts. Of these, six were further eliminated because they did not meet the inclusion requirements. At the conclusion of the study, Group 1 presented with 37.6% of subjects still testing positive for cysts; of Group 2, 12.5% tested positive; and in Group 3, 23.5% of participants tested positive for cysts (chi2 = 16.8; df = 2; p = 0.0002). For comparisons of groups 1 and 2 and 1 and 3, p < 0.05; for the comparison of groups 2 and 3, p > 0.05. We conclude that antiamoebic chemoprophylaxis can be a choice for control of amoebic infection where personal hygiene and food consumption habits are not improving.
Nicolas Padilla; Rosalinda Diaz; Alfonso Alarcon; Roberto Barreda
Related Documents :
23733104 - Warfarin use and long-term outcomes in patients with acute myocardial infarction and at...
23244784 - Prediction of graft patency and mortality after distal revascularization and interval l...
10764234 - The role of conservative management of vestibular schwannomas.
1520794 - Diloxanide furoate for treating asymptomatic entamoeba histolytica cyst passers: 14 yea...
14721994 - Less invasive cardiac anesthesia: an ultra-fast-track procedure avoiding thoracic epidu...
19528154 - Reduced susceptibility to amoxicillin of oral streptococci following amoxicillin exposure.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2002-04-20
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  2     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2003-06-13     Completed Date:  2004-09-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1070-8     Citation Subset:  IM    
Unidad de Investigacion, Escuela de Enfermeria y Obstetricia de Celaya, Universidad de Guanajuato, Searle de Mexico, S.A. de C.V.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amebicides / therapeutic use*
Chemoprevention / methods
Child, Preschool
Entamoeba histolytica / drug effects,  isolation & purification
Entamoebiasis / diagnosis,  drug therapy*,  prevention & control*
Feces / parasitology
Longitudinal Studies
Prospective Studies
Quinolines / therapeutic use*
Single-Blind Method
Treatment Outcome
Reg. No./Substance:
0/Amebicides; 0/Quinolines; 62265-68-3/quinfamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Field-based supercritical fluid extraction of hydrocarbons at industrially contaminated sites.
Next Document:  Determination and commitment of mechanosensory hair cells.