Document Detail


Antiallergic effect of KOB03, a polyherbal medicine, on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse and human mast cells.
MedLine Citation:
PMID:  22687252     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
ETHNOPHARMACOLOGICAL RELEVANCE: KOB03 is a polyherbal medicine consisting of five different herbs and has commonly been used for the treatment of various allergic diseases. However, its precise anti-allergic effect and mechanism remain unknown.
AIM OF THE STUDY: The aim of this study was to investigate the effect of KOB03 on allergic responses through the regulation of mast-cell mediated allergic inflammation.
MATERIALS AND METHODS: To determine the effect of KOB03 on mast cell-mediated allergic reactions, we investigated the parameter changes of in vivo models such as compound 48/80-induced systemic anaphylaxis and ovalbumin (OVA)-induced allergic rhinitis, and the release of allergic inflammatory mediators such as histamine, immunoglobulin (Ig) E, and inflammatory cytokines via the MAPKs and NF-kappaB pathways.
RESULTS: The oral administration of KOB03 at doses of 100 and 200mg/kg inhibited histamine release and mortality in compound 48/80-induced anaphylactic rats. KOB03 also improved rhinitis symptoms, inhibited the histopathological changes of nasal mucosa, and decreased the serum levels of histamine, OVA-specific IgE and TNF-α in OVA-induced allergic rhinitis in mice. In vitro, KOB03 suppressed compound 48/80-induced histamine release by blocking mast cell degranulation. In addition, KOB03 inhibited the production of inflammatory cytokines such as TNF-α, IL-1β, IL-6 and IL-8 in PMA/A23187-stimulated HMC-1 mast cells by suppressing their gene expression and blocking the ERK1/2 and p38 MAPK and NF-κB pathways.
CONCLUSIONS: These results suggest that KOB03 has an anti-allergic effect by modulating mast cell-mediated allergic responses in allergic rhinitis.
Authors:
Hyo Won Jung; Jin-Ki Jung; Cheong Weon Cho; Jong-Seong Kang; Yong-Ki Park
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-09
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  142     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-16     Completed Date:  2012-12-14     Revised Date:  2014-01-08    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  684-93     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Allergens
Angiosperms*
Animals
Anti-Allergic Agents / pharmacology,  therapeutic use*
Cell Line
Cytokines / blood,  genetics
Histamine Release / drug effects
Humans
Hypersensitivity, Immediate / chemically induced,  drug therapy*,  metabolism
Immunoglobulin E / blood
Male
Mast Cells / drug effects,  metabolism
Mice
Mice, Inbred BALB C
Mitogen-Activated Protein Kinases / metabolism
NF-kappa B / metabolism
Nasal Cavity
Ovalbumin
Phytotherapy*
Plant Extracts / pharmacology,  therapeutic use*
Plant Preparations / pharmacology,  therapeutic use*
RNA, Messenger / metabolism
Rhinitis / chemically induced,  drug therapy*,  metabolism
p-Methoxy-N-methylphenethylamine
Chemical
Reg. No./Substance:
0/Allergens; 0/Anti-Allergic Agents; 0/Cytokines; 0/KOB03; 0/NF-kappa B; 0/Plant Extracts; 0/Plant Preparations; 0/RNA, Messenger; 37341-29-0/Immunoglobulin E; 4091-50-3/p-Methoxy-N-methylphenethylamine; 9006-59-1/Ovalbumin; EC 2.7.11.24/Mitogen-Activated Protein Kinases

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