| Antiaging treatments have been legally prescribed for approximately thirty years. | |
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MedLine Citation:
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PMID: 15246996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is an interesting divergence between the achievements of geriatrics and gerontology. On the one hand, during the last 30 years physicians in many developed countries have successfully prescribed several medicines to cure various symptoms of senescence. On the other hand, the influence of such medicines on human life span practically has not been studied. The most common of the relevant medicines are nootropic piracetam, gamma-aminobutyric acid (GABA), selegiline, Ginkgo biloba, pentoxifylline, cerebrolysin, solcoseryl, ergoloid, vinpocetin, sertraline, and estrogens, among others. Available data from human clinical practices and experimental animal studies indicate that treatments with these drugs improve learning, memory, brain metabolism, and capacity. Some of these drugs increase tolerance to various stresses such as oxygen deficit and exercise, stimulate the regeneration of neurons in the old brain, and speed up the performance of mental and physical tasks. This means that modern medicine already has "antiaging" treatments at its disposal. However, the influence of such treatments on the mean and maximal life span of humans, and on the age trajectory of a human survival curve has been poorly studied. The increase in human life expectancy at birth in the second half of the last century was mostly caused by the better survival at the old and oldest old rather than at the young ages. In parallel, the consumption of brain protective and regenerative drugs has been expanding in the elderly population. We provide evidence in support of the idea that the consumption of medicines exerting antiaging properties may contribute to the increase in human longevity. |
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Authors:
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Svetlana V Ukraintseva; Konstantin G Arbeev; Anatoly I Michalsky; Anatoly I Yashin |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1019 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-07-12 Completed Date: 2004-08-20 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 64-9 Citation Subset: IM |
Affiliation:
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Max Planck Institute for Demographic Research, 18057 Rostock, Germany. ukraintseva@cds.duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Brain / drug effects, pathology Cognition Drug Prescriptions* Humans Longevity Oxygen / metabolism gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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56-12-2/gamma-Aminobutyric Acid; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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